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LOX-1 and Angiotensin Receptors, and Their Interplay
The renin-angiotensin system (RAS) plays an important role in regulating blood pressure, water-salt balance and the pathogenesis of cardiovascular diseases. Angiotensin II (Ang II) is the physiologically active mediator and mediates the main pathophysiological actions in RAS. Ang II exerts the effec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102029/ https://www.ncbi.nlm.nih.gov/pubmed/21861069 http://dx.doi.org/10.1007/s10557-011-6331-7 |
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author | Wang, Xianwei Phillips, M. Ian Mehta, Jawahar L. |
author_facet | Wang, Xianwei Phillips, M. Ian Mehta, Jawahar L. |
author_sort | Wang, Xianwei |
collection | PubMed |
description | The renin-angiotensin system (RAS) plays an important role in regulating blood pressure, water-salt balance and the pathogenesis of cardiovascular diseases. Angiotensin II (Ang II) is the physiologically active mediator and mediates the main pathophysiological actions in RAS. Ang II exerts the effects by activating its receptors, primarily type 1 (AT1R) and type 2 (AT2R). Most of the known pathophysiological effects of Ang II are mediated by AT1R activation. The precise physiological function of AT2R is still not clear. Generally, AT2R is considered to oppose the effects of AT1R. Lectin-like oxidized low-density lipoprotein scavenger receptor-1 (LOX-1) is one of the major receptors responsible for binding, internalizing and degrading ox-LDL. The activation of LOX-1 has been known to be related to many pathophysiological events, including endothelial dysfunction and injury, fibroblast growth, and vascular smooth muscle cell hypertrophy. Many of these alterations are present in atherosclerosis, hypertension, and myocardial ischemia and remodeling. A growing body of evidence suggests the existence of a cross-talk between LOX-1 and Ang II receptors. Their interplays are embodied in the reciprocal regulation of their expression and activity. Their interplays are involved in a series of signals. Recent studies suggests that reactive oxygen species (ROS), nitric oxide (NO), protein kinase C (PKC) and mitogen activated protein kinases (MAPKs) are important signals responsible for their cross-talk. This paper reviews these aspects of dyslipidemia and RAS activation. |
format | Online Article Text |
id | pubmed-7102029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-71020292020-03-31 LOX-1 and Angiotensin Receptors, and Their Interplay Wang, Xianwei Phillips, M. Ian Mehta, Jawahar L. Cardiovasc Drugs Ther Article The renin-angiotensin system (RAS) plays an important role in regulating blood pressure, water-salt balance and the pathogenesis of cardiovascular diseases. Angiotensin II (Ang II) is the physiologically active mediator and mediates the main pathophysiological actions in RAS. Ang II exerts the effects by activating its receptors, primarily type 1 (AT1R) and type 2 (AT2R). Most of the known pathophysiological effects of Ang II are mediated by AT1R activation. The precise physiological function of AT2R is still not clear. Generally, AT2R is considered to oppose the effects of AT1R. Lectin-like oxidized low-density lipoprotein scavenger receptor-1 (LOX-1) is one of the major receptors responsible for binding, internalizing and degrading ox-LDL. The activation of LOX-1 has been known to be related to many pathophysiological events, including endothelial dysfunction and injury, fibroblast growth, and vascular smooth muscle cell hypertrophy. Many of these alterations are present in atherosclerosis, hypertension, and myocardial ischemia and remodeling. A growing body of evidence suggests the existence of a cross-talk between LOX-1 and Ang II receptors. Their interplays are embodied in the reciprocal regulation of their expression and activity. Their interplays are involved in a series of signals. Recent studies suggests that reactive oxygen species (ROS), nitric oxide (NO), protein kinase C (PKC) and mitogen activated protein kinases (MAPKs) are important signals responsible for their cross-talk. This paper reviews these aspects of dyslipidemia and RAS activation. Springer US 2011-08-23 2011 /pmc/articles/PMC7102029/ /pubmed/21861069 http://dx.doi.org/10.1007/s10557-011-6331-7 Text en © Springer Science+Business Media, LLC 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Wang, Xianwei Phillips, M. Ian Mehta, Jawahar L. LOX-1 and Angiotensin Receptors, and Their Interplay |
title | LOX-1 and Angiotensin Receptors, and Their Interplay |
title_full | LOX-1 and Angiotensin Receptors, and Their Interplay |
title_fullStr | LOX-1 and Angiotensin Receptors, and Their Interplay |
title_full_unstemmed | LOX-1 and Angiotensin Receptors, and Their Interplay |
title_short | LOX-1 and Angiotensin Receptors, and Their Interplay |
title_sort | lox-1 and angiotensin receptors, and their interplay |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102029/ https://www.ncbi.nlm.nih.gov/pubmed/21861069 http://dx.doi.org/10.1007/s10557-011-6331-7 |
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