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Management of Acute Liver Failure: A Pediatric Perspective
PURPOSE OF REVIEW: Pediatric acute liver failure is a rare, complex, rapidly progressing, and life-threatening illness. Majority of pediatric acute liver failures have unknown etiology. This review intends to discuss the current literature on the challenging aspects of management of acute liver fail...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102106/ https://www.ncbi.nlm.nih.gov/pubmed/32288972 http://dx.doi.org/10.1007/s40124-018-0174-7 |
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author | Bhatt, Heli Rao, Girish S. |
author_facet | Bhatt, Heli Rao, Girish S. |
author_sort | Bhatt, Heli |
collection | PubMed |
description | PURPOSE OF REVIEW: Pediatric acute liver failure is a rare, complex, rapidly progressing, and life-threatening illness. Majority of pediatric acute liver failures have unknown etiology. This review intends to discuss the current literature on the challenging aspects of management of acute liver failure. RECENT FINDINGS: Collaborative multidisciplinary approach for management of patients with pediatric acute liver failure with upfront involvement of transplant hepatologist and critical care specialists can improve outcomes of this fatal disease. Extensive but systematic diagnostic evaluation can help to identify etiology and guide management. Early referral to a transplant center with prompt liver transplant, if indicated, can lead to improved survival in these patients. SUMMARY: Prompt identification and aggressive management of pediatric acute liver failure and related comorbidities can lead to increased transplant-free survival and improved post-transplant outcomes, thus decreasing mortality and morbidity associated with this potential fatal condition. |
format | Online Article Text |
id | pubmed-7102106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-71021062020-03-31 Management of Acute Liver Failure: A Pediatric Perspective Bhatt, Heli Rao, Girish S. Curr Pediatr Rep Gastrology (S Khan, Section Editor) PURPOSE OF REVIEW: Pediatric acute liver failure is a rare, complex, rapidly progressing, and life-threatening illness. Majority of pediatric acute liver failures have unknown etiology. This review intends to discuss the current literature on the challenging aspects of management of acute liver failure. RECENT FINDINGS: Collaborative multidisciplinary approach for management of patients with pediatric acute liver failure with upfront involvement of transplant hepatologist and critical care specialists can improve outcomes of this fatal disease. Extensive but systematic diagnostic evaluation can help to identify etiology and guide management. Early referral to a transplant center with prompt liver transplant, if indicated, can lead to improved survival in these patients. SUMMARY: Prompt identification and aggressive management of pediatric acute liver failure and related comorbidities can lead to increased transplant-free survival and improved post-transplant outcomes, thus decreasing mortality and morbidity associated with this potential fatal condition. Springer US 2018-05-15 2018 /pmc/articles/PMC7102106/ /pubmed/32288972 http://dx.doi.org/10.1007/s40124-018-0174-7 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Gastrology (S Khan, Section Editor) Bhatt, Heli Rao, Girish S. Management of Acute Liver Failure: A Pediatric Perspective |
title | Management of Acute Liver Failure: A Pediatric Perspective |
title_full | Management of Acute Liver Failure: A Pediatric Perspective |
title_fullStr | Management of Acute Liver Failure: A Pediatric Perspective |
title_full_unstemmed | Management of Acute Liver Failure: A Pediatric Perspective |
title_short | Management of Acute Liver Failure: A Pediatric Perspective |
title_sort | management of acute liver failure: a pediatric perspective |
topic | Gastrology (S Khan, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102106/ https://www.ncbi.nlm.nih.gov/pubmed/32288972 http://dx.doi.org/10.1007/s40124-018-0174-7 |
work_keys_str_mv | AT bhattheli managementofacuteliverfailureapediatricperspective AT raogirishs managementofacuteliverfailureapediatricperspective |