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Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza

PURPOSE: This paper describes the radiological and clinical findings identified in a group of patients with H1N1 influenza. MATERIALS AND METHODS: Between May and mid-November 2009, 3,649 patients with suspected H1N1 influenza presented to our hospital. Our study population comprised 167 (91 male, 7...

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Autores principales: Coppola, M., Porto, A., De Santo, D., De Fronzo, S., Grassi, R., Rotondo, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102231/
https://www.ncbi.nlm.nih.gov/pubmed/21225362
http://dx.doi.org/10.1007/s11547-011-0622-0
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author Coppola, M.
Porto, A.
De Santo, D.
De Fronzo, S.
Grassi, R.
Rotondo, A.
author_facet Coppola, M.
Porto, A.
De Santo, D.
De Fronzo, S.
Grassi, R.
Rotondo, A.
author_sort Coppola, M.
collection PubMed
description PURPOSE: This paper describes the radiological and clinical findings identified in a group of patients with H1N1 influenza. MATERIALS AND METHODS: Between May and mid-November 2009, 3,649 patients with suspected H1N1 influenza presented to our hospital. Our study population comprised 167 (91 male, 76 female patients, age range 11 months to 82 years; mean age 29 years) out of 1,896 patients with throat swab positive for H1N1 and clinical and laboratory findings indicative of viral influenza. All 167 patients were studied by chest X-ray (CXR), and 20 patients with positive CXR and worsening clinical condition also underwent computed tomography (CT). The following findings were evaluated on both modalities: interstitial reticulation (IR), nodules (N), ground-glass opacities (GGO), consolidations (CONS), bacterial superinfection and pulmonary complications. RESULTS: Ninety of 167 patients had positive CXR results. Abnormalities identified on CXR, variously combined and distributed, were as follows: 53 IR, 5 N, 13 GGO, 50 CONS; the predominant combination was represented by six GGO with CONS. Of the 20 CXR-positive cases also studied by CT, 17 showed pathological findings. The abnormalities identified on CT, variously combined and distributed, were as follows: 14 IR, 2 N, 5 GGO; the predominant combination was 10 GGO with CONS. Despite the differences between the two modalities, the principle radiological findings of bacterial superinfection were tree-in-bud pattern, consolidation with air bronchogram, and pleural and pericardial effusion. Fifteen of the 20 patients studied by both CXR and chest CT showed respiratory complications with bilateral and diffuse CONS on CXR and CT. Six of 15 died: 4/6 of acute respiratory distress syndrome and 2/6 of multiple organ failure. CONCLUSIONS: Our study describes the radiological and clinical characteristics of a large population of patients affected by H1N1 influenza. CXR and chest CT identified the site and extent of the pulmonary lesions and documented signs of bacterial superinfection and pulmonary complications.
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spelling pubmed-71022312020-03-31 Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza Coppola, M. Porto, A. De Santo, D. De Fronzo, S. Grassi, R. Rotondo, A. Radiol Med Chest Radiology / Radiologia Toracica PURPOSE: This paper describes the radiological and clinical findings identified in a group of patients with H1N1 influenza. MATERIALS AND METHODS: Between May and mid-November 2009, 3,649 patients with suspected H1N1 influenza presented to our hospital. Our study population comprised 167 (91 male, 76 female patients, age range 11 months to 82 years; mean age 29 years) out of 1,896 patients with throat swab positive for H1N1 and clinical and laboratory findings indicative of viral influenza. All 167 patients were studied by chest X-ray (CXR), and 20 patients with positive CXR and worsening clinical condition also underwent computed tomography (CT). The following findings were evaluated on both modalities: interstitial reticulation (IR), nodules (N), ground-glass opacities (GGO), consolidations (CONS), bacterial superinfection and pulmonary complications. RESULTS: Ninety of 167 patients had positive CXR results. Abnormalities identified on CXR, variously combined and distributed, were as follows: 53 IR, 5 N, 13 GGO, 50 CONS; the predominant combination was represented by six GGO with CONS. Of the 20 CXR-positive cases also studied by CT, 17 showed pathological findings. The abnormalities identified on CT, variously combined and distributed, were as follows: 14 IR, 2 N, 5 GGO; the predominant combination was 10 GGO with CONS. Despite the differences between the two modalities, the principle radiological findings of bacterial superinfection were tree-in-bud pattern, consolidation with air bronchogram, and pleural and pericardial effusion. Fifteen of the 20 patients studied by both CXR and chest CT showed respiratory complications with bilateral and diffuse CONS on CXR and CT. Six of 15 died: 4/6 of acute respiratory distress syndrome and 2/6 of multiple organ failure. CONCLUSIONS: Our study describes the radiological and clinical characteristics of a large population of patients affected by H1N1 influenza. CXR and chest CT identified the site and extent of the pulmonary lesions and documented signs of bacterial superinfection and pulmonary complications. Springer Milan 2011-01-12 2011 /pmc/articles/PMC7102231/ /pubmed/21225362 http://dx.doi.org/10.1007/s11547-011-0622-0 Text en © Springer-Verlag Italia 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Chest Radiology / Radiologia Toracica
Coppola, M.
Porto, A.
De Santo, D.
De Fronzo, S.
Grassi, R.
Rotondo, A.
Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza
title Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza
title_full Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza
title_fullStr Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza
title_full_unstemmed Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza
title_short Influenza A virus: radiological and clinical findings of patients hospitalised for pandemic H1N1 influenza
title_sort influenza a virus: radiological and clinical findings of patients hospitalised for pandemic h1n1 influenza
topic Chest Radiology / Radiologia Toracica
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102231/
https://www.ncbi.nlm.nih.gov/pubmed/21225362
http://dx.doi.org/10.1007/s11547-011-0622-0
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