Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

The development of new mechanisms of resistance among pathogens, the occurrence and transmission of genes responsible for antibiotic insensitivity, as well as cancer diseases have been a serious clinical problem around the world for over 50 years. Therefore, intense searching of new leading structur...

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Detalles Bibliográficos
Autores principales: Wróbel, Agnieszka, Arciszewska, Karolina, Maliszewski, Dawid, Drozdowska, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102388/
https://www.ncbi.nlm.nih.gov/pubmed/31578455
http://dx.doi.org/10.1038/s41429-019-0240-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102388/
https://www.ncbi.nlm.nih.gov/pubmed/31578455
http://dx.doi.org/10.1038/s41429-019-0240-6

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