Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant

Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Adeline Yi Ling, Mattke, Adrian Christian, Clark, Julia Elizabeth, Pinzon-Charry, Alberto, Alphonso, Nelson, Kapur, Nitin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102488/
https://www.ncbi.nlm.nih.gov/pubmed/32257491
http://dx.doi.org/10.1155/2020/5740304
_version_ 1783511836616818688
author Lim, Adeline Yi Ling
Mattke, Adrian Christian
Clark, Julia Elizabeth
Pinzon-Charry, Alberto
Alphonso, Nelson
Kapur, Nitin
author_facet Lim, Adeline Yi Ling
Mattke, Adrian Christian
Clark, Julia Elizabeth
Pinzon-Charry, Alberto
Alphonso, Nelson
Kapur, Nitin
author_sort Lim, Adeline Yi Ling
collection PubMed
description Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy. The infant required cardiorespiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. This case highlights the potential for severe acquired immunodeficiency in this patient cohort and further postnatal surveillance is highly recommended.
format Online
Article
Text
id pubmed-7102488
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-71024882020-04-01 Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant Lim, Adeline Yi Ling Mattke, Adrian Christian Clark, Julia Elizabeth Pinzon-Charry, Alberto Alphonso, Nelson Kapur, Nitin Case Rep Pediatr Case Report Pneumocystis jirovecii is recognized as an opportunistic pathogen in immunosuppressed patients. We report a case of severe Pneumocystis pneumonia (PCP) in an infant with acquired combined immunodeficiency secondary to maternal chemotherapy exposure during the second and third trimesters of pregnancy. The infant required cardiorespiratory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. This case highlights the potential for severe acquired immunodeficiency in this patient cohort and further postnatal surveillance is highly recommended. Hindawi 2020-03-15 /pmc/articles/PMC7102488/ /pubmed/32257491 http://dx.doi.org/10.1155/2020/5740304 Text en Copyright © 2020 Adeline Yi Ling Lim et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lim, Adeline Yi Ling
Mattke, Adrian Christian
Clark, Julia Elizabeth
Pinzon-Charry, Alberto
Alphonso, Nelson
Kapur, Nitin
Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant
title Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant
title_full Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant
title_fullStr Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant
title_full_unstemmed Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant
title_short Acquired Immunodeficiency from Maternal Chemotherapy and Severe Primary Pneumocystis Infection in an Infant
title_sort acquired immunodeficiency from maternal chemotherapy and severe primary pneumocystis infection in an infant
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102488/
https://www.ncbi.nlm.nih.gov/pubmed/32257491
http://dx.doi.org/10.1155/2020/5740304
work_keys_str_mv AT limadelineyiling acquiredimmunodeficiencyfrommaternalchemotherapyandsevereprimarypneumocystisinfectioninaninfant
AT mattkeadrianchristian acquiredimmunodeficiencyfrommaternalchemotherapyandsevereprimarypneumocystisinfectioninaninfant
AT clarkjuliaelizabeth acquiredimmunodeficiencyfrommaternalchemotherapyandsevereprimarypneumocystisinfectioninaninfant
AT pinzoncharryalberto acquiredimmunodeficiencyfrommaternalchemotherapyandsevereprimarypneumocystisinfectioninaninfant
AT alphonsonelson acquiredimmunodeficiencyfrommaternalchemotherapyandsevereprimarypneumocystisinfectioninaninfant
AT kapurnitin acquiredimmunodeficiencyfrommaternalchemotherapyandsevereprimarypneumocystisinfectioninaninfant

Ejemplares similares