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2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
OBJECTIVES: Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)]...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102618/ https://www.ncbi.nlm.nih.gov/pubmed/32156648 http://dx.doi.org/10.1016/j.jgar.2020.02.021 |
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author | Lupia, Tommaso Scabini, Silvia Mornese Pinna, Simone Di Perri, Giovanni De Rosa, Francesco Giuseppe Corcione, Silvia |
author_facet | Lupia, Tommaso Scabini, Silvia Mornese Pinna, Simone Di Perri, Giovanni De Rosa, Francesco Giuseppe Corcione, Silvia |
author_sort | Lupia, Tommaso |
collection | PubMed |
description | OBJECTIVES: Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. METHODS: The currently available literature was reviewed for microbiologically confirmed infections by 2019-nCoV or COVID-19 at the time of writing (13 February 2020). A literature search was performed using the PubMed database and Cochrane Library. Search terms included ‘novel coronavirus’ or ‘2019-nCoV’ or ‘COVID-19’. RESULTS: Published cases occurred mostly in males (age range, 8–92 years). Cardiovascular, digestive and endocrine system diseases were commonly reported, except previous chronic pulmonary diseases [e.g. chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis] that were surprisingly underreported. Fever was present in all of the case series available, flanked by cough, dyspnoea, myalgia and fatigue. Multiple bilateral lobular and subsegmental areas of consolidation or bilateral ground-glass opacities were the main reported radiological features of 2019-nCoV infection, at least in the early phases of the disease. CONCLUSION: The new 2019-nCoV epidemic is mainly associated with respiratory disease and few extrapulmonary signs. However, there is a low rate of associated pre-existing respiratory co-morbidities. |
format | Online Article Text |
id | pubmed-7102618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71026182020-03-31 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge Lupia, Tommaso Scabini, Silvia Mornese Pinna, Simone Di Perri, Giovanni De Rosa, Francesco Giuseppe Corcione, Silvia J Glob Antimicrob Resist Article OBJECTIVES: Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. METHODS: The currently available literature was reviewed for microbiologically confirmed infections by 2019-nCoV or COVID-19 at the time of writing (13 February 2020). A literature search was performed using the PubMed database and Cochrane Library. Search terms included ‘novel coronavirus’ or ‘2019-nCoV’ or ‘COVID-19’. RESULTS: Published cases occurred mostly in males (age range, 8–92 years). Cardiovascular, digestive and endocrine system diseases were commonly reported, except previous chronic pulmonary diseases [e.g. chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis] that were surprisingly underreported. Fever was present in all of the case series available, flanked by cough, dyspnoea, myalgia and fatigue. Multiple bilateral lobular and subsegmental areas of consolidation or bilateral ground-glass opacities were the main reported radiological features of 2019-nCoV infection, at least in the early phases of the disease. CONCLUSION: The new 2019-nCoV epidemic is mainly associated with respiratory disease and few extrapulmonary signs. However, there is a low rate of associated pre-existing respiratory co-morbidities. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. 2020-06 2020-03-07 /pmc/articles/PMC7102618/ /pubmed/32156648 http://dx.doi.org/10.1016/j.jgar.2020.02.021 Text en © 2020 Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Lupia, Tommaso Scabini, Silvia Mornese Pinna, Simone Di Perri, Giovanni De Rosa, Francesco Giuseppe Corcione, Silvia 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge |
title | 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge |
title_full | 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge |
title_fullStr | 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge |
title_full_unstemmed | 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge |
title_short | 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge |
title_sort | 2019 novel coronavirus (2019-ncov) outbreak: a new challenge |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102618/ https://www.ncbi.nlm.nih.gov/pubmed/32156648 http://dx.doi.org/10.1016/j.jgar.2020.02.021 |
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