Cargando…

2019 novel coronavirus (2019-nCoV) outbreak: A new challenge

OBJECTIVES: Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)]...

Descripción completa

Detalles Bibliográficos
Autores principales: Lupia, Tommaso, Scabini, Silvia, Mornese Pinna, Simone, Di Perri, Giovanni, De Rosa, Francesco Giuseppe, Corcione, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102618/
https://www.ncbi.nlm.nih.gov/pubmed/32156648
http://dx.doi.org/10.1016/j.jgar.2020.02.021
_version_ 1783511869614456832
author Lupia, Tommaso
Scabini, Silvia
Mornese Pinna, Simone
Di Perri, Giovanni
De Rosa, Francesco Giuseppe
Corcione, Silvia
author_facet Lupia, Tommaso
Scabini, Silvia
Mornese Pinna, Simone
Di Perri, Giovanni
De Rosa, Francesco Giuseppe
Corcione, Silvia
author_sort Lupia, Tommaso
collection PubMed
description OBJECTIVES: Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. METHODS: The currently available literature was reviewed for microbiologically confirmed infections by 2019-nCoV or COVID-19 at the time of writing (13 February 2020). A literature search was performed using the PubMed database and Cochrane Library. Search terms included ‘novel coronavirus’ or ‘2019-nCoV’ or ‘COVID-19’. RESULTS: Published cases occurred mostly in males (age range, 8–92 years). Cardiovascular, digestive and endocrine system diseases were commonly reported, except previous chronic pulmonary diseases [e.g. chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis] that were surprisingly underreported. Fever was present in all of the case series available, flanked by cough, dyspnoea, myalgia and fatigue. Multiple bilateral lobular and subsegmental areas of consolidation or bilateral ground-glass opacities were the main reported radiological features of 2019-nCoV infection, at least in the early phases of the disease. CONCLUSION: The new 2019-nCoV epidemic is mainly associated with respiratory disease and few extrapulmonary signs. However, there is a low rate of associated pre-existing respiratory co-morbidities.
format Online
Article
Text
id pubmed-7102618
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.
record_format MEDLINE/PubMed
spelling pubmed-71026182020-03-31 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge Lupia, Tommaso Scabini, Silvia Mornese Pinna, Simone Di Perri, Giovanni De Rosa, Francesco Giuseppe Corcione, Silvia J Glob Antimicrob Resist Article OBJECTIVES: Following the public-health emergency of international concern (PHEIC) declared by the World Health Organization (WHO) on 30 January 2020 and the recent outbreak caused by 2019 novel coronavirus (2019-nCoV) [officially renamed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] in China and 29 other countries, we aimed to summarise the clinical aspects of the novelBetacoronavirus disease (COVID-19) and its possible clinical presentations together with suggested therapeutic algorithms for patients who may require antimicrobial treatment. METHODS: The currently available literature was reviewed for microbiologically confirmed infections by 2019-nCoV or COVID-19 at the time of writing (13 February 2020). A literature search was performed using the PubMed database and Cochrane Library. Search terms included ‘novel coronavirus’ or ‘2019-nCoV’ or ‘COVID-19’. RESULTS: Published cases occurred mostly in males (age range, 8–92 years). Cardiovascular, digestive and endocrine system diseases were commonly reported, except previous chronic pulmonary diseases [e.g. chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis] that were surprisingly underreported. Fever was present in all of the case series available, flanked by cough, dyspnoea, myalgia and fatigue. Multiple bilateral lobular and subsegmental areas of consolidation or bilateral ground-glass opacities were the main reported radiological features of 2019-nCoV infection, at least in the early phases of the disease. CONCLUSION: The new 2019-nCoV epidemic is mainly associated with respiratory disease and few extrapulmonary signs. However, there is a low rate of associated pre-existing respiratory co-morbidities. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. 2020-06 2020-03-07 /pmc/articles/PMC7102618/ /pubmed/32156648 http://dx.doi.org/10.1016/j.jgar.2020.02.021 Text en © 2020 Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lupia, Tommaso
Scabini, Silvia
Mornese Pinna, Simone
Di Perri, Giovanni
De Rosa, Francesco Giuseppe
Corcione, Silvia
2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
title 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
title_full 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
title_fullStr 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
title_full_unstemmed 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
title_short 2019 novel coronavirus (2019-nCoV) outbreak: A new challenge
title_sort 2019 novel coronavirus (2019-ncov) outbreak: a new challenge
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102618/
https://www.ncbi.nlm.nih.gov/pubmed/32156648
http://dx.doi.org/10.1016/j.jgar.2020.02.021
work_keys_str_mv AT lupiatommaso 2019novelcoronavirus2019ncovoutbreakanewchallenge
AT scabinisilvia 2019novelcoronavirus2019ncovoutbreakanewchallenge
AT mornesepinnasimone 2019novelcoronavirus2019ncovoutbreakanewchallenge
AT diperrigiovanni 2019novelcoronavirus2019ncovoutbreakanewchallenge
AT derosafrancescogiuseppe 2019novelcoronavirus2019ncovoutbreakanewchallenge
AT corcionesilvia 2019novelcoronavirus2019ncovoutbreakanewchallenge