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Put a cork in it: Plugging the M2 viral ion channel to sink influenza
The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an establ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102647/ https://www.ncbi.nlm.nih.gov/pubmed/32229237 http://dx.doi.org/10.1016/j.antiviral.2020.104780 |
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author | Jalily, Pouria H. Duncan, Maggie C. Fedida, David Wang, Jun Tietjen, Ian |
author_facet | Jalily, Pouria H. Duncan, Maggie C. Fedida, David Wang, Jun Tietjen, Ian |
author_sort | Jalily, Pouria H. |
collection | PubMed |
description | The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strains that these drugs are no longer recommended. Here we review the current understanding of IAV M2 structure and function, mechanisms of inhibition, the rise of drug resistance mutations, and ongoing efforts to develop new antivirals that target resistant forms of M2. |
format | Online Article Text |
id | pubmed-7102647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71026472020-03-31 Put a cork in it: Plugging the M2 viral ion channel to sink influenza Jalily, Pouria H. Duncan, Maggie C. Fedida, David Wang, Jun Tietjen, Ian Antiviral Res Article The ongoing threat of seasonal and pandemic influenza to human health requires antivirals that can effectively supplement existing vaccination strategies. The M2 protein of influenza A virus (IAV) is a proton-gated, proton-selective ion channel that is required for virus replication and is an established antiviral target. While licensed adamantane-based M2 antivirals have been historically used, M2 mutations that confer major adamantane resistance are now so prevalent in circulating virus strains that these drugs are no longer recommended. Here we review the current understanding of IAV M2 structure and function, mechanisms of inhibition, the rise of drug resistance mutations, and ongoing efforts to develop new antivirals that target resistant forms of M2. Elsevier B.V. 2020-06 2020-03-27 /pmc/articles/PMC7102647/ /pubmed/32229237 http://dx.doi.org/10.1016/j.antiviral.2020.104780 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Jalily, Pouria H. Duncan, Maggie C. Fedida, David Wang, Jun Tietjen, Ian Put a cork in it: Plugging the M2 viral ion channel to sink influenza |
title | Put a cork in it: Plugging the M2 viral ion channel to sink influenza |
title_full | Put a cork in it: Plugging the M2 viral ion channel to sink influenza |
title_fullStr | Put a cork in it: Plugging the M2 viral ion channel to sink influenza |
title_full_unstemmed | Put a cork in it: Plugging the M2 viral ion channel to sink influenza |
title_short | Put a cork in it: Plugging the M2 viral ion channel to sink influenza |
title_sort | put a cork in it: plugging the m2 viral ion channel to sink influenza |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102647/ https://www.ncbi.nlm.nih.gov/pubmed/32229237 http://dx.doi.org/10.1016/j.antiviral.2020.104780 |
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