Molecular basis of COVID-19 relationships in different species: a one health perspective

Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of “unconventional” biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviru...

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Autores principales: Tilocca, Bruno, Soggiu, Alessio, Musella, Vincenzo, Britti, Domenico, Sanguinetti, Maurizio, Urbani, Andrea, Roncada, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institut Pasteur. Published by Elsevier Masson SAS. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102648/
https://www.ncbi.nlm.nih.gov/pubmed/32194253
http://dx.doi.org/10.1016/j.micinf.2020.03.002
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author Tilocca, Bruno
Soggiu, Alessio
Musella, Vincenzo
Britti, Domenico
Sanguinetti, Maurizio
Urbani, Andrea
Roncada, Paola
author_facet Tilocca, Bruno
Soggiu, Alessio
Musella, Vincenzo
Britti, Domenico
Sanguinetti, Maurizio
Urbani, Andrea
Roncada, Paola
author_sort Tilocca, Bruno
collection PubMed
description Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of “unconventional” biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.
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spelling pubmed-71026482020-03-31 Molecular basis of COVID-19 relationships in different species: a one health perspective Tilocca, Bruno Soggiu, Alessio Musella, Vincenzo Britti, Domenico Sanguinetti, Maurizio Urbani, Andrea Roncada, Paola Microbes Infect Article Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of “unconventional” biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses. Institut Pasteur. Published by Elsevier Masson SAS. 2020 2020-03-17 /pmc/articles/PMC7102648/ /pubmed/32194253 http://dx.doi.org/10.1016/j.micinf.2020.03.002 Text en © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tilocca, Bruno
Soggiu, Alessio
Musella, Vincenzo
Britti, Domenico
Sanguinetti, Maurizio
Urbani, Andrea
Roncada, Paola
Molecular basis of COVID-19 relationships in different species: a one health perspective
title Molecular basis of COVID-19 relationships in different species: a one health perspective
title_full Molecular basis of COVID-19 relationships in different species: a one health perspective
title_fullStr Molecular basis of COVID-19 relationships in different species: a one health perspective
title_full_unstemmed Molecular basis of COVID-19 relationships in different species: a one health perspective
title_short Molecular basis of COVID-19 relationships in different species: a one health perspective
title_sort molecular basis of covid-19 relationships in different species: a one health perspective
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102648/
https://www.ncbi.nlm.nih.gov/pubmed/32194253
http://dx.doi.org/10.1016/j.micinf.2020.03.002
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