Cargando…

Inhibition of viral RNA polymerases by nucleoside and nucleotide analogs: therapeutic applications against positive-strand RNA viruses beyond hepatitis C virus

A number of important human infections are caused by positive-strand RNA viruses, yet almost none can be treated with small molecule antiviral therapeutics. One exception is the chronic infection caused by hepatitis C virus (HCV), against which new generations of potent inhibitors are being develope...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deval, Jerome, Symons, Julian A, Beigelman, Leo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier B.V. 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102778/ https://www.ncbi.nlm.nih.gov/pubmed/25194816 http://dx.doi.org/10.1016/j.coviro.2014.08.004

Ejemplares similares

Assessment of nucleotide/nucleoside analog intervention in primer-dependent viral RNA-dependent RNA polymerases
por: Liu, Qiaojie, et al.
Publicado: (2022)

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase
por: Jordan, Paul C., et al.
Publicado: (2018)

Nucleosides for the treatment of respiratory RNA virus infections
por: Jordan, Paul C, et al.
Publicado: (2018)

Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases
por: Shareef, Afzaal M., et al.
Publicado: (2021)

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY
por: Jin, Zhinan, et al.
Publicado: (2011)

Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs
por: Maheden, Kieran, et al.
Publicado: (2021)

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase
por: Deval, Jerome, et al.
Publicado: (2016)

Nucleoside Analogs That Inhibit SARS-CoV-2 Replication by Blocking Interaction of Virus Polymerase with RNA
por: Matyugina, Elena, et al.
Publicado: (2023)

Within and Beyond the Nucleotide Addition Cycle of Viral RNA-dependent RNA Polymerases
por: Gong, Peng
Publicado: (2022)

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate
por: Deval, Jerome, et al.
Publicado: (2015)

Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase
por: Xu, Tiantian, et al.
Publicado: (2023)

Recapitulating Trafficking of Nucleosides Into the Active Site of Polymerases of RNA Viruses: The Challenge and the Prize
por: Boulard, Yves, et al.
Publicado: (2021)

Dissecting nucleotide selectivity in viral RNA polymerases
por: Long, Chunhong, et al.
Publicado: (2021)

RNA Synthesis and Capping by Non-segmented Negative Strand RNA Viral Polymerases: Lessons From a Prototypic Virus
por: Ogino, Tomoaki, et al.
Publicado: (2019)

Mechanisms of inhibition of viral RNA replication by nucleotide analogs
por: Johnson, Kenneth A., et al.
Publicado: (2021)

Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants
por: Lam, Angela M., et al.
Publicado: (2017)

RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication
por: Nikonov, Andrei, et al.
Publicado: (2013)

Inhibition of Viral RNA-Dependent RNA Polymerases by Nucleoside Inhibitors: An Illustration of the Unity and Diversity of Mechanisms
por: Barik, Sailen
Publicado: (2022)

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
por: Feng, Joy Y., et al.
Publicado: (2016)

Visualizing the Nucleotide Addition Cycle of Viral RNA-Dependent RNA Polymerase
por: Wu, Jiqin, et al.
Publicado: (2018)

Adherence to Treatment with Oral Nucleoside/Nucleotide Analogs in Patients with Chronic Hepatitis B
por: Ozyigitoglu, Derya, et al.
Publicado: (2022)

Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond
por: Chaudhuri, Shuvam, et al.
Publicado: (2018)

Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs
por: Gmeiner, William H.
Publicado: (2019)

2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
por: Uemura, Kentaro, et al.
Publicado: (2023)

Nucleoproteins of Negative Strand RNA Viruses; RNA Binding, Oligomerisation and Binding to Polymerase Co-Factor
por: Ruigrok, Rob W.H., et al.
Publicado: (2010)

Nucleoside analogs in ADAR guide strands targeting 5′-UA̲ sites
por: Brinkman, Hannah F., et al.
Publicado: (2022)

Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses
por: Deval, Jerome, et al.
Publicado: (2017)

Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study
por: Qi, Weili, et al.
Publicado: (2021)

An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus
por: Horie, Masayuki, et al.
Publicado: (2016)

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses
por: Jia, Hengxia, et al.
Publicado: (2019)

Exploring the Emergence of RNA Nucleosides and Nucleotides on the Early Earth
por: Biscans, Annabelle
Publicado: (2018)

Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses
por: Ahlquist, Paul
Publicado: (2006)

Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and Dynamics
por: Sesmero, Ester, et al.
Publicado: (2015)

Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers
por: Dulin, David, et al.
Publicado: (2017)

CryoEM of Viral Ribonucleoproteins and Nucleocapsids of Single-Stranded RNA Viruses
por: Modrego, Andrea, et al.
Publicado: (2023)

Plus-Strand RNA Viruses
por: STRAUSS, JAMES H., et al.
Publicado: (2008)

Minus-Strand RNA Viruses
por: STRAUSS, JAMES H., et al.
Publicado: (2008)

Single-Stranded RNA Viruses
por: Lvov, Dimitry Konstantinovich, et al.
Publicado: (2015)

Advances in antiviral nucleoside analogues and their prodrugs
por: Seley-Radtke, Katherine, et al.
Publicado: (2018)

Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus
por: Cheng, Xin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_81e6vno94bgq8dn4nebo9cvb85