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Using transgenic plants and modified plant viruses for the development of treatments for human diseases
Production of proteins in plants for human health applications has become an attractive strategy attributed by their potentials for low-cost production, increased safety due to the lack of human or animal pathogens, scalability and ability to produce complex proteins. A major milestone for plant-bas...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102806/ https://www.ncbi.nlm.nih.gov/pubmed/28800551 http://dx.doi.org/10.1016/j.coviro.2017.07.019 |
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author | Loh, Hwei-San Green, Brian J Yusibov, Vidadi |
author_facet | Loh, Hwei-San Green, Brian J Yusibov, Vidadi |
author_sort | Loh, Hwei-San |
collection | PubMed |
description | Production of proteins in plants for human health applications has become an attractive strategy attributed by their potentials for low-cost production, increased safety due to the lack of human or animal pathogens, scalability and ability to produce complex proteins. A major milestone for plant-based protein production for use in human health was achieved when Protalix BioTherapeutics produced taliglucerase alfa (Elelyso(®)) in suspension cultures of a transgenic carrot cell line for the treatment of patients with Gaucher's disease, was approved by the USA Food and Drug Administration in 2012. In this review, we are highlighting various approaches for plant-based production of proteins and recent progress in the development of plant-made therapeutics and biologics for the prevention and treatment of human diseases. |
format | Online Article Text |
id | pubmed-7102806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71028062020-03-31 Using transgenic plants and modified plant viruses for the development of treatments for human diseases Loh, Hwei-San Green, Brian J Yusibov, Vidadi Curr Opin Virol Article Production of proteins in plants for human health applications has become an attractive strategy attributed by their potentials for low-cost production, increased safety due to the lack of human or animal pathogens, scalability and ability to produce complex proteins. A major milestone for plant-based protein production for use in human health was achieved when Protalix BioTherapeutics produced taliglucerase alfa (Elelyso(®)) in suspension cultures of a transgenic carrot cell line for the treatment of patients with Gaucher's disease, was approved by the USA Food and Drug Administration in 2012. In this review, we are highlighting various approaches for plant-based production of proteins and recent progress in the development of plant-made therapeutics and biologics for the prevention and treatment of human diseases. Elsevier B.V. 2017-10 2017-08-08 /pmc/articles/PMC7102806/ /pubmed/28800551 http://dx.doi.org/10.1016/j.coviro.2017.07.019 Text en © 2017 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Loh, Hwei-San Green, Brian J Yusibov, Vidadi Using transgenic plants and modified plant viruses for the development of treatments for human diseases |
title | Using transgenic plants and modified plant viruses for the development of treatments for human diseases |
title_full | Using transgenic plants and modified plant viruses for the development of treatments for human diseases |
title_fullStr | Using transgenic plants and modified plant viruses for the development of treatments for human diseases |
title_full_unstemmed | Using transgenic plants and modified plant viruses for the development of treatments for human diseases |
title_short | Using transgenic plants and modified plant viruses for the development of treatments for human diseases |
title_sort | using transgenic plants and modified plant viruses for the development of treatments for human diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102806/ https://www.ncbi.nlm.nih.gov/pubmed/28800551 http://dx.doi.org/10.1016/j.coviro.2017.07.019 |
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