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Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies
Stress necessitates rapid reprogramming of translation in order to facilitate an adaptive response and promote survival. Cytoplasmic stress granules (SGs) and processing bodies (PBs) are dynamic structures that form in response to stress-induced translational arrest. PBs are linked to mRNA silencing...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102815/ https://www.ncbi.nlm.nih.gov/pubmed/20374741 http://dx.doi.org/10.1016/S1877-1173(09)90004-7 |
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author | Kedersha, Nancy Anderson, Paul |
author_facet | Kedersha, Nancy Anderson, Paul |
author_sort | Kedersha, Nancy |
collection | PubMed |
description | Stress necessitates rapid reprogramming of translation in order to facilitate an adaptive response and promote survival. Cytoplasmic stress granules (SGs) and processing bodies (PBs) are dynamic structures that form in response to stress-induced translational arrest. PBs are linked to mRNA silencing and decay, while SGs are more closely linked to translation and the sorting of specific mRNAs for different fates. While they share some components and can interact physically, SGs and PBs are regulated independently, house separate functions, and contain unique markers. SG formation is associated with numerous disease states, and the expanding list of SG-associated proteins integrates SG formation with other processes such as transcription, splicing, and survival. Growing evidence suggests that SG assembly is initiated by translational arrest, and mediates cross talk with many other signaling pathways. |
format | Online Article Text |
id | pubmed-7102815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71028152020-03-31 Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies Kedersha, Nancy Anderson, Paul Prog Mol Biol Transl Sci Article Stress necessitates rapid reprogramming of translation in order to facilitate an adaptive response and promote survival. Cytoplasmic stress granules (SGs) and processing bodies (PBs) are dynamic structures that form in response to stress-induced translational arrest. PBs are linked to mRNA silencing and decay, while SGs are more closely linked to translation and the sorting of specific mRNAs for different fates. While they share some components and can interact physically, SGs and PBs are regulated independently, house separate functions, and contain unique markers. SG formation is associated with numerous disease states, and the expanding list of SG-associated proteins integrates SG formation with other processes such as transcription, splicing, and survival. Growing evidence suggests that SG assembly is initiated by translational arrest, and mediates cross talk with many other signaling pathways. Elsevier Inc. 2009 2009-10-27 /pmc/articles/PMC7102815/ /pubmed/20374741 http://dx.doi.org/10.1016/S1877-1173(09)90004-7 Text en Copyright © 2009 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Kedersha, Nancy Anderson, Paul Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies |
title | Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies |
title_full | Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies |
title_fullStr | Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies |
title_full_unstemmed | Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies |
title_short | Chapter 4 Regulation of Translation by Stress Granules and Processing Bodies |
title_sort | chapter 4 regulation of translation by stress granules and processing bodies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102815/ https://www.ncbi.nlm.nih.gov/pubmed/20374741 http://dx.doi.org/10.1016/S1877-1173(09)90004-7 |
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