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Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes

OBJECTIVE: Heterozygous loss-of-function mutations in HNF1A cause maturity-onset diabetes of the young (MODY). Affected individuals can be treated with low-dose sulfonylureas. Individuals with homozygous HNF1A mutations causing MODY have not been reported. RESEARCH DESIGN AND METHODS: We phenotyped...

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Detalles Bibliográficos
Autores principales:	Misra, Shivani, Hassanali, Neelam, Bennett, Amanda J., Juszczak, Agata, Caswell, Richard, Colclough, Kevin, Valabhji, Jonathan, Ellard, Sian, Oliver, Nicholas S., Gloyn, Anna L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Novel Communications in Diabetes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102871/ https://www.ncbi.nlm.nih.gov/pubmed/32001615 http://dx.doi.org/10.2337/dc19-1843

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