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N (1)-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells

Synthetic messenger RNA (mRNA) tools often use pseudouridine and 5-methyl cytidine as substitutions for uridine and cytidine to avoid the immune response and cytotoxicity induced by introducing mRNA into cells. However, the influence of base modifications on the functionality of the RNA tools is poo...

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Detalles Bibliográficos
Autores principales:	Parr, Callum J C, Wada, Shunsuke, Kotake, Kenjiro, Kameda, Shigetoshi, Matsuura, Satoshi, Sakashita, Souhei, Park, Soyoung, Sugiyama, Hiroshi, Kuang, Yi, Saito, Hirohide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102939/ https://www.ncbi.nlm.nih.gov/pubmed/32090264 http://dx.doi.org/10.1093/nar/gkaa070

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