An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype

The RNA-editing protein ADAR is essential for early development in the mouse. Genetic evidence suggests that A to I editing marks endogenous RNAs as ‘self’. Today, different Adar knockout alleles have been generated that show a common phenotype of apoptosis, liver disintegration, elevated immune res...

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Detalles Bibliográficos
Autores principales: Bajad, Prajakta, Ebner, Florian, Amman, Fabian, Szabó, Brigitta, Kapoor, Utkarsh, Manjali, Greeshma, Hildebrandt, Alwine, Janisiw, Michael P, Jantsch, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102943/
https://www.ncbi.nlm.nih.gov/pubmed/31956894
http://dx.doi.org/10.1093/nar/gkaa025

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