PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2

Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found that PRMT5 inhibition or depletion led to more genes being downregulated than upregul...

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Detalles Bibliográficos
Autores principales: Liu, Fan, Xu, Ye, Lu, Xiaoqing, Hamard, Pierre-Jacques, Karl, Daniel L, Man, Na, Mookhtiar, Adnan K, Martinez, Concepcion, Lossos, Izidore S, Sun, Jun, Nimer, Stephen D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102951/
https://www.ncbi.nlm.nih.gov/pubmed/32025719
http://dx.doi.org/10.1093/nar/gkaa065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102951/
https://www.ncbi.nlm.nih.gov/pubmed/32025719
http://dx.doi.org/10.1093/nar/gkaa065

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