Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ

SFPQ is a ubiquitous nuclear RNA-binding protein implicated in many aspects of RNA biogenesis. Importantly, nuclear depletion and cytoplasmic accumulation of SFPQ has been linked to neuropathological conditions such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). Here, we d...

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Detalles Bibliográficos
Autores principales: Huang, Jie, Ringuet, Mitchell, Whitten, Andrew E, Caria, Sofia, Lim, Yee Wa, Badhan, Rahul, Anggono, Victor, Lee, Mihwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102971/
https://www.ncbi.nlm.nih.gov/pubmed/32034402
http://dx.doi.org/10.1093/nar/gkaa076

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