The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels

During protein synthesis, charged tRNAs deliver amino acids to translating ribosomes, and are then re-charged by tRNA synthetases (aaRS). In humans, mutant aaRS cause a diversity of neurological disorders, but their molecular aetiologies are incompletely characterised. To understand system responses...

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Detalles Bibliográficos
Autores principales: McFarland, Matthew R, Keller, Corina D, Childers, Brandon M, Adeniyi, Stephen A, Corrigall, Holly, Raguin, Adélaïde, Romano, M Carmen, Stansfield, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102972/
https://www.ncbi.nlm.nih.gov/pubmed/32016368
http://dx.doi.org/10.1093/nar/gkaa055

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