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Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup

BACKGROUND: Multi-organ dysfunction in critical illness is common and frequently involves the lungs and kidneys, often requiring organ support such as invasive mechanical ventilation (IMV), renal replacement therapy (RRT) and/or extracorporeal membrane oxygenation (ECMO). METHODS: A consensus confer...

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Autores principales: Joannidis, Michael, Forni, Lui G., Klein, Sebastian J., Honore, Patrick M., Kashani, Kianoush, Ostermann, Marlies, Prowle, John, Bagshaw, Sean M., Cantaluppi, Vincenzo, Darmon, Michael, Ding, Xiaoqiang, Fuhrmann, Valentin, Hoste, Eric, Husain-Syed, Faeq, Lubnow, Matthias, Maggiorini, Marco, Meersch, Melanie, Murray, Patrick T., Ricci, Zaccaria, Singbartl, Kai, Staudinger, Thomas, Welte, Tobias, Ronco, Claudio, Kellum, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103017/
https://www.ncbi.nlm.nih.gov/pubmed/31820034
http://dx.doi.org/10.1007/s00134-019-05869-7
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author Joannidis, Michael
Forni, Lui G.
Klein, Sebastian J.
Honore, Patrick M.
Kashani, Kianoush
Ostermann, Marlies
Prowle, John
Bagshaw, Sean M.
Cantaluppi, Vincenzo
Darmon, Michael
Ding, Xiaoqiang
Fuhrmann, Valentin
Hoste, Eric
Husain-Syed, Faeq
Lubnow, Matthias
Maggiorini, Marco
Meersch, Melanie
Murray, Patrick T.
Ricci, Zaccaria
Singbartl, Kai
Staudinger, Thomas
Welte, Tobias
Ronco, Claudio
Kellum, John A.
author_facet Joannidis, Michael
Forni, Lui G.
Klein, Sebastian J.
Honore, Patrick M.
Kashani, Kianoush
Ostermann, Marlies
Prowle, John
Bagshaw, Sean M.
Cantaluppi, Vincenzo
Darmon, Michael
Ding, Xiaoqiang
Fuhrmann, Valentin
Hoste, Eric
Husain-Syed, Faeq
Lubnow, Matthias
Maggiorini, Marco
Meersch, Melanie
Murray, Patrick T.
Ricci, Zaccaria
Singbartl, Kai
Staudinger, Thomas
Welte, Tobias
Ronco, Claudio
Kellum, John A.
author_sort Joannidis, Michael
collection PubMed
description BACKGROUND: Multi-organ dysfunction in critical illness is common and frequently involves the lungs and kidneys, often requiring organ support such as invasive mechanical ventilation (IMV), renal replacement therapy (RRT) and/or extracorporeal membrane oxygenation (ECMO). METHODS: A consensus conference on the spectrum of lung–kidney interactions in critical illness was held under the auspices of the Acute Disease Quality Initiative (ADQI) in Innsbruck, Austria, in June 2018. Through review and critical appraisal of the available evidence, the current state of research, and both clinical and research recommendations were described on the following topics: epidemiology, pathophysiology and strategies to mitigate pulmonary dysfunction among patients with acute kidney injury and/or kidney dysfunction among patients with acute respiratory failure/acute respiratory distress syndrome. Furthermore, emphasis was put on patients receiving organ support (RRT, IMV and/or ECMO) and its impact on lung and kidney function. CONCLUSION: The ADQI 21 conference found significant knowledge gaps about organ crosstalk between lung and kidney and its relevance for critically ill patients. Lung protective ventilation, conservative fluid management and early recognition and treatment of pulmonary infections were the only clinical recommendations with higher quality of evidence. Recommendations for research were formulated, targeting lung–kidney interactions to improve care processes and outcomes in critical illness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-019-05869-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-71030172020-03-30 Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup Joannidis, Michael Forni, Lui G. Klein, Sebastian J. Honore, Patrick M. Kashani, Kianoush Ostermann, Marlies Prowle, John Bagshaw, Sean M. Cantaluppi, Vincenzo Darmon, Michael Ding, Xiaoqiang Fuhrmann, Valentin Hoste, Eric Husain-Syed, Faeq Lubnow, Matthias Maggiorini, Marco Meersch, Melanie Murray, Patrick T. Ricci, Zaccaria Singbartl, Kai Staudinger, Thomas Welte, Tobias Ronco, Claudio Kellum, John A. Intensive Care Med Conference Reports and Expert Panel BACKGROUND: Multi-organ dysfunction in critical illness is common and frequently involves the lungs and kidneys, often requiring organ support such as invasive mechanical ventilation (IMV), renal replacement therapy (RRT) and/or extracorporeal membrane oxygenation (ECMO). METHODS: A consensus conference on the spectrum of lung–kidney interactions in critical illness was held under the auspices of the Acute Disease Quality Initiative (ADQI) in Innsbruck, Austria, in June 2018. Through review and critical appraisal of the available evidence, the current state of research, and both clinical and research recommendations were described on the following topics: epidemiology, pathophysiology and strategies to mitigate pulmonary dysfunction among patients with acute kidney injury and/or kidney dysfunction among patients with acute respiratory failure/acute respiratory distress syndrome. Furthermore, emphasis was put on patients receiving organ support (RRT, IMV and/or ECMO) and its impact on lung and kidney function. CONCLUSION: The ADQI 21 conference found significant knowledge gaps about organ crosstalk between lung and kidney and its relevance for critically ill patients. Lung protective ventilation, conservative fluid management and early recognition and treatment of pulmonary infections were the only clinical recommendations with higher quality of evidence. Recommendations for research were formulated, targeting lung–kidney interactions to improve care processes and outcomes in critical illness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-019-05869-7) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-12-09 2020 /pmc/articles/PMC7103017/ /pubmed/31820034 http://dx.doi.org/10.1007/s00134-019-05869-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Conference Reports and Expert Panel
Joannidis, Michael
Forni, Lui G.
Klein, Sebastian J.
Honore, Patrick M.
Kashani, Kianoush
Ostermann, Marlies
Prowle, John
Bagshaw, Sean M.
Cantaluppi, Vincenzo
Darmon, Michael
Ding, Xiaoqiang
Fuhrmann, Valentin
Hoste, Eric
Husain-Syed, Faeq
Lubnow, Matthias
Maggiorini, Marco
Meersch, Melanie
Murray, Patrick T.
Ricci, Zaccaria
Singbartl, Kai
Staudinger, Thomas
Welte, Tobias
Ronco, Claudio
Kellum, John A.
Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup
title Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup
title_full Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup
title_fullStr Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup
title_full_unstemmed Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup
title_short Lung–kidney interactions in critically ill patients: consensus report of the Acute Disease Quality Initiative (ADQI) 21 Workgroup
title_sort lung–kidney interactions in critically ill patients: consensus report of the acute disease quality initiative (adqi) 21 workgroup
topic Conference Reports and Expert Panel
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103017/
https://www.ncbi.nlm.nih.gov/pubmed/31820034
http://dx.doi.org/10.1007/s00134-019-05869-7
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