Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form

Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year...

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Autores principales: Ben Nacef, Ibtissem, Mekni, Sabrine, Mhedhebi, Chedi, Riahi, Ines, Rojbi, Imen, Nadia, Mchirgui, Khiari, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103030/
https://www.ncbi.nlm.nih.gov/pubmed/32257462
http://dx.doi.org/10.1155/2020/6284764
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author Ben Nacef, Ibtissem
Mekni, Sabrine
Mhedhebi, Chedi
Riahi, Ines
Rojbi, Imen
Nadia, Mchirgui
Khiari, Karima
author_facet Ben Nacef, Ibtissem
Mekni, Sabrine
Mhedhebi, Chedi
Riahi, Ines
Rojbi, Imen
Nadia, Mchirgui
Khiari, Karima
author_sort Ben Nacef, Ibtissem
collection PubMed
description Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare.
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spelling pubmed-71030302020-04-01 Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form Ben Nacef, Ibtissem Mekni, Sabrine Mhedhebi, Chedi Riahi, Ines Rojbi, Imen Nadia, Mchirgui Khiari, Karima Case Rep Endocrinol Case Report Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare. Hindawi 2020-03-17 /pmc/articles/PMC7103030/ /pubmed/32257462 http://dx.doi.org/10.1155/2020/6284764 Text en Copyright © 2020 Ibtissem Ben Nacef et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ben Nacef, Ibtissem
Mekni, Sabrine
Mhedhebi, Chedi
Riahi, Ines
Rojbi, Imen
Nadia, Mchirgui
Khiari, Karima
Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
title Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
title_full Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
title_fullStr Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
title_full_unstemmed Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
title_short Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form
title_sort langerhans cell histiocytosis of the thyroid leading to the diagnosis of a disseminated form
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103030/
https://www.ncbi.nlm.nih.gov/pubmed/32257462
http://dx.doi.org/10.1155/2020/6284764
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