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T cell epitope: Friend or Foe? Immunogenicity of biologics in context()
Like vaccines, biologic proteins can be very immunogenic for reasons including route of administration, dose frequency and the underlying antigenicity of the therapeutic protein. Because the impact of immunogenicity can be quite severe, regulatory agencies are developing risk-based guidelines for im...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier B.V.
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103283/ https://www.ncbi.nlm.nih.gov/pubmed/19619593 http://dx.doi.org/10.1016/j.addr.2009.07.001 |