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Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
Cystic fibrosis (CF), a condition produced by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator, is the most prevalent autosomal-recessive hereditary disease in caucasian populations. Among other repercussions, this defect leads to an alteration of respirator...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier España, S.L.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103330/ https://www.ncbi.nlm.nih.gov/pubmed/19232782 http://dx.doi.org/10.1016/j.eimc.2008.05.004 |
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author | Oliver, Antonio Alarcón, Teresa Caballero, Estrella Cantón, Rafael |
author_facet | Oliver, Antonio Alarcón, Teresa Caballero, Estrella Cantón, Rafael |
author_sort | Oliver, Antonio |
collection | PubMed |
description | Cystic fibrosis (CF), a condition produced by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator, is the most prevalent autosomal-recessive hereditary disease in caucasian populations. Among other repercussions, this defect leads to an alteration of respiratory secretions and determines a predisposition for chronic bronchopulmonary colonization-infection, which is the main driver of the high morbidity and early mortality of CF patients. Colonization by Staphylococcus aureus and Haemophilus influenzae is frequent in children younger than 10 years, but mucoid Pseudomonas aeruginosa is by far the most relevant pathogen in adults with CF and is responsible for the progressive bronchopulmonary deterioration. As a consequence of repeated, long-lasting antimicrobial treatments and deterioration of lung function, colonization by multidrug-resistant Gram-negative bacilli, such as Stenotrophomonas maltophilia, Achromobacter spp. and Burkholderia cepacia complex, is also frequent in adult CF patients. The special characteristics of the pathologic process and the microorganisms implicated in CF make it advisable to consider microbiological follow-up of chronic bronchopulmonary colonization-infection in these patients a specific diagnostic entity. |
format | Online Article Text |
id | pubmed-7103330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Elsevier España, S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71033302020-03-31 Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística Oliver, Antonio Alarcón, Teresa Caballero, Estrella Cantón, Rafael Enferm Infecc Microbiol Clin Article Cystic fibrosis (CF), a condition produced by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator, is the most prevalent autosomal-recessive hereditary disease in caucasian populations. Among other repercussions, this defect leads to an alteration of respiratory secretions and determines a predisposition for chronic bronchopulmonary colonization-infection, which is the main driver of the high morbidity and early mortality of CF patients. Colonization by Staphylococcus aureus and Haemophilus influenzae is frequent in children younger than 10 years, but mucoid Pseudomonas aeruginosa is by far the most relevant pathogen in adults with CF and is responsible for the progressive bronchopulmonary deterioration. As a consequence of repeated, long-lasting antimicrobial treatments and deterioration of lung function, colonization by multidrug-resistant Gram-negative bacilli, such as Stenotrophomonas maltophilia, Achromobacter spp. and Burkholderia cepacia complex, is also frequent in adult CF patients. The special characteristics of the pathologic process and the microorganisms implicated in CF make it advisable to consider microbiological follow-up of chronic bronchopulmonary colonization-infection in these patients a specific diagnostic entity. Elsevier España, S.L. 2009-02 2009-02-20 /pmc/articles/PMC7103330/ /pubmed/19232782 http://dx.doi.org/10.1016/j.eimc.2008.05.004 Text en Copyright © 2008 Elsevier España, S.L. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Oliver, Antonio Alarcón, Teresa Caballero, Estrella Cantón, Rafael Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística |
title | Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística |
title_full | Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística |
title_fullStr | Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística |
title_full_unstemmed | Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística |
title_short | Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística |
title_sort | diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103330/ https://www.ncbi.nlm.nih.gov/pubmed/19232782 http://dx.doi.org/10.1016/j.eimc.2008.05.004 |
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