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Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística

Cystic fibrosis (CF), a condition produced by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator, is the most prevalent autosomal-recessive hereditary disease in caucasian populations. Among other repercussions, this defect leads to an alteration of respirator...

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Autores principales: Oliver, Antonio, Alarcón, Teresa, Caballero, Estrella, Cantón, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier España, S.L. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103330/
https://www.ncbi.nlm.nih.gov/pubmed/19232782
http://dx.doi.org/10.1016/j.eimc.2008.05.004
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author Oliver, Antonio
Alarcón, Teresa
Caballero, Estrella
Cantón, Rafael
author_facet Oliver, Antonio
Alarcón, Teresa
Caballero, Estrella
Cantón, Rafael
author_sort Oliver, Antonio
collection PubMed
description Cystic fibrosis (CF), a condition produced by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator, is the most prevalent autosomal-recessive hereditary disease in caucasian populations. Among other repercussions, this defect leads to an alteration of respiratory secretions and determines a predisposition for chronic bronchopulmonary colonization-infection, which is the main driver of the high morbidity and early mortality of CF patients. Colonization by Staphylococcus aureus and Haemophilus influenzae is frequent in children younger than 10 years, but mucoid Pseudomonas aeruginosa is by far the most relevant pathogen in adults with CF and is responsible for the progressive bronchopulmonary deterioration. As a consequence of repeated, long-lasting antimicrobial treatments and deterioration of lung function, colonization by multidrug-resistant Gram-negative bacilli, such as Stenotrophomonas maltophilia, Achromobacter spp. and Burkholderia cepacia complex, is also frequent in adult CF patients. The special characteristics of the pathologic process and the microorganisms implicated in CF make it advisable to consider microbiological follow-up of chronic bronchopulmonary colonization-infection in these patients a specific diagnostic entity.
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spelling pubmed-71033302020-03-31 Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística Oliver, Antonio Alarcón, Teresa Caballero, Estrella Cantón, Rafael Enferm Infecc Microbiol Clin Article Cystic fibrosis (CF), a condition produced by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator, is the most prevalent autosomal-recessive hereditary disease in caucasian populations. Among other repercussions, this defect leads to an alteration of respiratory secretions and determines a predisposition for chronic bronchopulmonary colonization-infection, which is the main driver of the high morbidity and early mortality of CF patients. Colonization by Staphylococcus aureus and Haemophilus influenzae is frequent in children younger than 10 years, but mucoid Pseudomonas aeruginosa is by far the most relevant pathogen in adults with CF and is responsible for the progressive bronchopulmonary deterioration. As a consequence of repeated, long-lasting antimicrobial treatments and deterioration of lung function, colonization by multidrug-resistant Gram-negative bacilli, such as Stenotrophomonas maltophilia, Achromobacter spp. and Burkholderia cepacia complex, is also frequent in adult CF patients. The special characteristics of the pathologic process and the microorganisms implicated in CF make it advisable to consider microbiological follow-up of chronic bronchopulmonary colonization-infection in these patients a specific diagnostic entity. Elsevier España, S.L. 2009-02 2009-02-20 /pmc/articles/PMC7103330/ /pubmed/19232782 http://dx.doi.org/10.1016/j.eimc.2008.05.004 Text en Copyright © 2008 Elsevier España, S.L. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Oliver, Antonio
Alarcón, Teresa
Caballero, Estrella
Cantón, Rafael
Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
title Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
title_full Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
title_fullStr Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
title_full_unstemmed Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
title_short Diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
title_sort diagnóstico microbiológico de la colonización-infección broncopulmonar en el paciente con fibrosis quística
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103330/
https://www.ncbi.nlm.nih.gov/pubmed/19232782
http://dx.doi.org/10.1016/j.eimc.2008.05.004
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