Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition

Many viruses encode antagonists to prevent interferon (IFN) induction. Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN ind...

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Autores principales: Versteeg, Gijs A., Bredenbeek, Peter J., van den Worm, Sjoerd H.E., Spaan, Willy J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2007
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103335/
https://www.ncbi.nlm.nih.gov/pubmed/17316733
http://dx.doi.org/10.1016/j.virol.2007.01.020
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author Versteeg, Gijs A.
Bredenbeek, Peter J.
van den Worm, Sjoerd H.E.
Spaan, Willy J.M.
author_facet Versteeg, Gijs A.
Bredenbeek, Peter J.
van den Worm, Sjoerd H.E.
Spaan, Willy J.M.
author_sort Versteeg, Gijs A.
collection PubMed
description Many viruses encode antagonists to prevent interferon (IFN) induction. Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN induction, and induction of IFN mRNA transcription. Furthermore, MHV and SARS-CoV infection could not prevent IFN induction by poly (I:C) or Sendai virus, suggesting that these CoVs do not inactivate IRF3-mediated transcription regulation, but apparently prevent detection of replicative RNA by cellular sensory molecules. Our data indicate that shielding of viral RNA to host cell sensors might be the main general mechanism for coronaviruses to prevent IFN induction.
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spelling pubmed-71033352020-03-31 Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition Versteeg, Gijs A. Bredenbeek, Peter J. van den Worm, Sjoerd H.E. Spaan, Willy J.M. Virology Rapid Communication Many viruses encode antagonists to prevent interferon (IFN) induction. Infection of fibroblasts with the murine hepatitis coronavirus (MHV) and SARS-coronavirus (SARS-CoV) did not result in nuclear translocation of interferon-regulatory factor 3 (IRF3), a key transcription factor involved in IFN induction, and induction of IFN mRNA transcription. Furthermore, MHV and SARS-CoV infection could not prevent IFN induction by poly (I:C) or Sendai virus, suggesting that these CoVs do not inactivate IRF3-mediated transcription regulation, but apparently prevent detection of replicative RNA by cellular sensory molecules. Our data indicate that shielding of viral RNA to host cell sensors might be the main general mechanism for coronaviruses to prevent IFN induction. Elsevier Inc. 2007-04-25 2007-02-21 /pmc/articles/PMC7103335/ /pubmed/17316733 http://dx.doi.org/10.1016/j.virol.2007.01.020 Text en Copyright © 2007 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Rapid Communication
Versteeg, Gijs A.
Bredenbeek, Peter J.
van den Worm, Sjoerd H.E.
Spaan, Willy J.M.
Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition
title Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition
title_full Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition
title_fullStr Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition
title_full_unstemmed Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition
title_short Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition
title_sort group 2 coronaviruses prevent immediate early interferon induction by protection of viral rna from host cell recognition
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103335/
https://www.ncbi.nlm.nih.gov/pubmed/17316733
http://dx.doi.org/10.1016/j.virol.2007.01.020
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