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Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS
The SARS-CoV spike glycoprotein (S) is the main target of the protective immune response in humans and animal models of SARS. Here, we demonstrated that efficient expression of S from the wild-type spike gene in cultured cells required the use of improved plasmid vectors containing donor and accepto...
Autores principales: | Callendret, Benoît, Lorin, Valérie, Charneau, Pierre, Marianneau, Philippe, Contamin, Hugues, Betton, Jean-Michel, van der Werf, Sylvie, Escriou, Nicolas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103356/ https://www.ncbi.nlm.nih.gov/pubmed/17331558 http://dx.doi.org/10.1016/j.virol.2007.01.012 |
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