Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure()

The 3C-like protease of SARS coronavirus (SARS-CoV 3CL(pro)) is vital for SARS-CoV replication and is a promising drug target. It has been extensively proved that only the dimeric enzyme is active. Here we discovered that two adjacent mutations (Ser139_Ala and Phe140_Ala) on the dimer interface resu...

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Detalles Bibliográficos
Autores principales: Hu, Tiancen, Zhang, Yu, Li, Lianwei, Wang, Kuifeng, Chen, Shuai, Chen, Jing, Ding, Jianping, Jiang, Hualiang, Shen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103376/
https://www.ncbi.nlm.nih.gov/pubmed/19409595
http://dx.doi.org/10.1016/j.virol.2009.03.034

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