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Proteolytic processing of polyproteins 1a and 1ab between non-structural proteins 10 and 11/12 of Coronavirus infectious bronchitis virus is dispensable for viral replication in cultured cells

Coronavirus 3C-like proteinase (3CLpro) plays important roles in viral life cycle through extensive processing of the polyproteins 1a and 1ab into 12 mature, non-structural proteins (nsp5–nsp16). Structural and biochemical studies have revealed that all confirmed 3CLpro cleavage sites have a conserv...

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Detalles Bibliográficos
Autores principales:	Fang, Shou Guo, Shen, Hongyuan, Wang, Jibin, Tay, Felicia P.L., Liu, Ding Xiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2008
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103401/ https://www.ncbi.nlm.nih.gov/pubmed/18678384 http://dx.doi.org/10.1016/j.virol.2008.06.038

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