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Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin

BACKGROUND/OBJECTIVES: Obesity is a global epidemic and the underlying basis for numerous comorbidities. We report that the aryl hydrocarbon receptor (AHR) plays a key role in the metabolism of obesity. The AHR is a promiscuous, ligand-activated nuclear receptor primarily known for regulating genes...

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Detalles Bibliográficos
Autores principales:	Rojas, Itzel Y., Moyer, Benjamin J., Ringelberg, Carol S., Tomlinson, Craig R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103522/ https://www.ncbi.nlm.nih.gov/pubmed/31911663 http://dx.doi.org/10.1038/s41366-019-0512-z

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