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Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration
Here we report the case of successful immune tolerance induction in a living‐donor kidney transplant recipient remotely treated with autologous bone marrow‐derived mesenchymal stromal cells (MSC). This case report, which to the best of our knowledge is the first in the world in this setting, provide...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103624/ https://www.ncbi.nlm.nih.gov/pubmed/31872574 http://dx.doi.org/10.1002/sctm.19-0185 |
| _version_ | 1783512086112894976 |
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| author | Casiraghi, Federica Perico, Norberto Gotti, Eliana Todeschini, Marta Mister, Marilena Cortinovis, Monica Portalupi, Valentina Plati, Anna Rita Gaspari, Flavio Villa, Alessandro Introna, Martino Longhi, Elena Remuzzi, Giuseppe |
| author_facet | Casiraghi, Federica Perico, Norberto Gotti, Eliana Todeschini, Marta Mister, Marilena Cortinovis, Monica Portalupi, Valentina Plati, Anna Rita Gaspari, Flavio Villa, Alessandro Introna, Martino Longhi, Elena Remuzzi, Giuseppe |
| author_sort | Casiraghi, Federica |
| collection | PubMed |
| description | Here we report the case of successful immune tolerance induction in a living‐donor kidney transplant recipient remotely treated with autologous bone marrow‐derived mesenchymal stromal cells (MSC). This case report, which to the best of our knowledge is the first in the world in this setting, provides evidence that the modulation of the host immune system with MSC can enable the safe withdrawal of maintenance immunosuppressive drugs while preserving optimal long‐term kidney allograft function. |
| format | Online Article Text |
| id | pubmed-7103624 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley & Sons, Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71036242020-03-31 Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration Casiraghi, Federica Perico, Norberto Gotti, Eliana Todeschini, Marta Mister, Marilena Cortinovis, Monica Portalupi, Valentina Plati, Anna Rita Gaspari, Flavio Villa, Alessandro Introna, Martino Longhi, Elena Remuzzi, Giuseppe Stem Cells Transl Med Human Clinical Article Here we report the case of successful immune tolerance induction in a living‐donor kidney transplant recipient remotely treated with autologous bone marrow‐derived mesenchymal stromal cells (MSC). This case report, which to the best of our knowledge is the first in the world in this setting, provides evidence that the modulation of the host immune system with MSC can enable the safe withdrawal of maintenance immunosuppressive drugs while preserving optimal long‐term kidney allograft function. John Wiley & Sons, Inc. 2019-12-24 /pmc/articles/PMC7103624/ /pubmed/31872574 http://dx.doi.org/10.1002/sctm.19-0185 Text en © 2019 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Human Clinical Article Casiraghi, Federica Perico, Norberto Gotti, Eliana Todeschini, Marta Mister, Marilena Cortinovis, Monica Portalupi, Valentina Plati, Anna Rita Gaspari, Flavio Villa, Alessandro Introna, Martino Longhi, Elena Remuzzi, Giuseppe Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration |
| title | Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration |
| title_full | Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration |
| title_fullStr | Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration |
| title_full_unstemmed | Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration |
| title_short | Kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration |
| title_sort | kidney transplant tolerance associated with remote autologous mesenchymal stromal cell administration |
| topic | Human Clinical Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103624/ https://www.ncbi.nlm.nih.gov/pubmed/31872574 http://dx.doi.org/10.1002/sctm.19-0185 |
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