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Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)

OBJECTIVE: We evaluated atrial fibrillation (AF) patients’ perceptions of anticoagulation treatment with dabigatran or a vitamin K antagonist (VKA) for stroke prevention, according to accepted indications. METHODS: The RE-SONANCE observational, prospective, multicentre, international study used the...

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Autores principales: Vinereanu, Dragos, Napalkov, Dmitry, Bergler-Klein, Jutta, Benczur, Bela, Ciernik, Martin, Gotcheva, Nina, Medvedchikov, Alexey, Põder, Pentti, Simic, Dragan, Skride, Andris, Tang, Wenbo, Trusz-Gluza, Maria, Vesely, Jiri, Vishnepolsky, Tatiana, Vrabec, Mirej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103803/
https://www.ncbi.nlm.nih.gov/pubmed/32257246
http://dx.doi.org/10.1136/openhrt-2019-001202
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author Vinereanu, Dragos
Napalkov, Dmitry
Bergler-Klein, Jutta
Benczur, Bela
Ciernik, Martin
Gotcheva, Nina
Medvedchikov, Alexey
Põder, Pentti
Simic, Dragan
Skride, Andris
Tang, Wenbo
Trusz-Gluza, Maria
Vesely, Jiri
Vishnepolsky, Tatiana
Vrabec, Mirej
author_facet Vinereanu, Dragos
Napalkov, Dmitry
Bergler-Klein, Jutta
Benczur, Bela
Ciernik, Martin
Gotcheva, Nina
Medvedchikov, Alexey
Põder, Pentti
Simic, Dragan
Skride, Andris
Tang, Wenbo
Trusz-Gluza, Maria
Vesely, Jiri
Vishnepolsky, Tatiana
Vrabec, Mirej
author_sort Vinereanu, Dragos
collection PubMed
description OBJECTIVE: We evaluated atrial fibrillation (AF) patients’ perceptions of anticoagulation treatment with dabigatran or a vitamin K antagonist (VKA) for stroke prevention, according to accepted indications. METHODS: The RE-SONANCE observational, prospective, multicentre, international study used the validated Perception on Anticoagulant Treatment Questionnaire (PACT-Q) to assess patients with AF already taking a VKA who were switched to dabigatran (cohort A), and newly diagnosed patients initiated on either dabigatran or a VKA (cohort B). Visit 1 (V1) was at baseline, and visit 2 (V2) and visit 3 (V3) were at 30–45 and 150–210 days after baseline, respectively. Primary outcomes were treatment satisfaction and convenience in cohort A at V2 and V3 versus baseline, and in cohort B for dabigatran and a VKA at V2 and V3. RESULTS: The main analysis set comprised 4100 patients in cohort A and 5365 in cohort B (dabigatran: 3179; VKA: 2186). In cohort A, PACT-Q2 improved significantly (p<0.001 for all) for treatment convenience (mean change V1 vs V2=20.72; SD=21.50; V1 vs V3=24.54; SD=22.85) and treatment satisfaction (mean change V1 vs V2=17.60; SD=18.76; V1 vs V3=21.04; SD=20.24). In cohort B, mean PACT-Q2 scores at V2 and V3 were significantly higher (p<0.001 for all) for dabigatran versus a VKA for treatment convenience (V2=18.38; SE =0.51; V3=23.34; SE=0.51) and satisfaction (V2=15.88; SE=0.39; V3=19.01; SE=0.41). CONCLUSIONS: Switching to dabigatran from long-term VKA therapy or newly initiated dabigatran is associated with improved patient treatment convenience and satisfaction compared with VKA therapy.
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spelling pubmed-71038032020-03-31 Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study) Vinereanu, Dragos Napalkov, Dmitry Bergler-Klein, Jutta Benczur, Bela Ciernik, Martin Gotcheva, Nina Medvedchikov, Alexey Põder, Pentti Simic, Dragan Skride, Andris Tang, Wenbo Trusz-Gluza, Maria Vesely, Jiri Vishnepolsky, Tatiana Vrabec, Mirej Open Heart Arrhythmias and Sudden Death OBJECTIVE: We evaluated atrial fibrillation (AF) patients’ perceptions of anticoagulation treatment with dabigatran or a vitamin K antagonist (VKA) for stroke prevention, according to accepted indications. METHODS: The RE-SONANCE observational, prospective, multicentre, international study used the validated Perception on Anticoagulant Treatment Questionnaire (PACT-Q) to assess patients with AF already taking a VKA who were switched to dabigatran (cohort A), and newly diagnosed patients initiated on either dabigatran or a VKA (cohort B). Visit 1 (V1) was at baseline, and visit 2 (V2) and visit 3 (V3) were at 30–45 and 150–210 days after baseline, respectively. Primary outcomes were treatment satisfaction and convenience in cohort A at V2 and V3 versus baseline, and in cohort B for dabigatran and a VKA at V2 and V3. RESULTS: The main analysis set comprised 4100 patients in cohort A and 5365 in cohort B (dabigatran: 3179; VKA: 2186). In cohort A, PACT-Q2 improved significantly (p<0.001 for all) for treatment convenience (mean change V1 vs V2=20.72; SD=21.50; V1 vs V3=24.54; SD=22.85) and treatment satisfaction (mean change V1 vs V2=17.60; SD=18.76; V1 vs V3=21.04; SD=20.24). In cohort B, mean PACT-Q2 scores at V2 and V3 were significantly higher (p<0.001 for all) for dabigatran versus a VKA for treatment convenience (V2=18.38; SE =0.51; V3=23.34; SE=0.51) and satisfaction (V2=15.88; SE=0.39; V3=19.01; SE=0.41). CONCLUSIONS: Switching to dabigatran from long-term VKA therapy or newly initiated dabigatran is associated with improved patient treatment convenience and satisfaction compared with VKA therapy. BMJ Publishing Group 2020-03-24 /pmc/articles/PMC7103803/ /pubmed/32257246 http://dx.doi.org/10.1136/openhrt-2019-001202 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Arrhythmias and Sudden Death
Vinereanu, Dragos
Napalkov, Dmitry
Bergler-Klein, Jutta
Benczur, Bela
Ciernik, Martin
Gotcheva, Nina
Medvedchikov, Alexey
Põder, Pentti
Simic, Dragan
Skride, Andris
Tang, Wenbo
Trusz-Gluza, Maria
Vesely, Jiri
Vishnepolsky, Tatiana
Vrabec, Mirej
Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)
title Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)
title_full Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)
title_fullStr Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)
title_full_unstemmed Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)
title_short Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)
title_sort patient perception of anticoagulant treatment for stroke prevention (re-sonance study)
topic Arrhythmias and Sudden Death
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103803/
https://www.ncbi.nlm.nih.gov/pubmed/32257246
http://dx.doi.org/10.1136/openhrt-2019-001202
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