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Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer
Pulmonary infection is a relatively rare but serious complication of flexible bronchoscopy. The aim of this study was to identify the risk factors for pulmonary infectious complications after diagnostic bronchoscopy in patients with lung cancer. We retrospectively analyzed the medical records of 636...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nagoya University
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103861/ https://www.ncbi.nlm.nih.gov/pubmed/32273634 http://dx.doi.org/10.18999/nagjms.82.1.69 |
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author | Shimizu, Takahiro Okachi, Shotaro Imai, Naoyuki Hase, Tetsunari Morise, Masahiro Hashimoto, Naozumi Sato, Mitsuo Hasegawa, Yoshinori |
author_facet | Shimizu, Takahiro Okachi, Shotaro Imai, Naoyuki Hase, Tetsunari Morise, Masahiro Hashimoto, Naozumi Sato, Mitsuo Hasegawa, Yoshinori |
author_sort | Shimizu, Takahiro |
collection | PubMed |
description | Pulmonary infection is a relatively rare but serious complication of flexible bronchoscopy. The aim of this study was to identify the risk factors for pulmonary infectious complications after diagnostic bronchoscopy in patients with lung cancer. We retrospectively analyzed the medical records of 636 patients who underwent bronchoscopic biopsy for lung cancer diagnosis between April 2011 and March 2016. We compared patients’ characteristics, chest computed tomography and bronchoscopic findings, undertaken procedures, and final diagnoses between patients who developed the complication and those who did not. Pulmonary infection after the diagnostic bronchoscopy occurred in 19 patients (3.0%) and included pneumonia in 16 patients and lung abscess in 3. Patients with larger lesions, presence of endobronchial lesions, histology of small cell lung cancer, and advanced disease stage tended to develop pulmonary infectious complications more often. Our multivariate analysis revealed that a larger lesion size and the presence of endobronchial lesions were independently associated with post-bronchoscopy pulmonary infection. Although we found no mortality associated with the infections, two patients were left with significant performance status deterioration after the pulmonary infection and received no anticancer treatment. In conclusion, endobronchial lesions and a larger lesion size are independent risk factors for the incidence of infections following bronchoscopic biopsy in patients with lung cancer. |
format | Online Article Text |
id | pubmed-7103861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nagoya University |
record_format | MEDLINE/PubMed |
spelling | pubmed-71038612020-04-09 Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer Shimizu, Takahiro Okachi, Shotaro Imai, Naoyuki Hase, Tetsunari Morise, Masahiro Hashimoto, Naozumi Sato, Mitsuo Hasegawa, Yoshinori Nagoya J Med Sci Original Paper Pulmonary infection is a relatively rare but serious complication of flexible bronchoscopy. The aim of this study was to identify the risk factors for pulmonary infectious complications after diagnostic bronchoscopy in patients with lung cancer. We retrospectively analyzed the medical records of 636 patients who underwent bronchoscopic biopsy for lung cancer diagnosis between April 2011 and March 2016. We compared patients’ characteristics, chest computed tomography and bronchoscopic findings, undertaken procedures, and final diagnoses between patients who developed the complication and those who did not. Pulmonary infection after the diagnostic bronchoscopy occurred in 19 patients (3.0%) and included pneumonia in 16 patients and lung abscess in 3. Patients with larger lesions, presence of endobronchial lesions, histology of small cell lung cancer, and advanced disease stage tended to develop pulmonary infectious complications more often. Our multivariate analysis revealed that a larger lesion size and the presence of endobronchial lesions were independently associated with post-bronchoscopy pulmonary infection. Although we found no mortality associated with the infections, two patients were left with significant performance status deterioration after the pulmonary infection and received no anticancer treatment. In conclusion, endobronchial lesions and a larger lesion size are independent risk factors for the incidence of infections following bronchoscopic biopsy in patients with lung cancer. Nagoya University 2020-02 /pmc/articles/PMC7103861/ /pubmed/32273634 http://dx.doi.org/10.18999/nagjms.82.1.69 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Paper Shimizu, Takahiro Okachi, Shotaro Imai, Naoyuki Hase, Tetsunari Morise, Masahiro Hashimoto, Naozumi Sato, Mitsuo Hasegawa, Yoshinori Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer |
title | Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer |
title_full | Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer |
title_fullStr | Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer |
title_full_unstemmed | Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer |
title_short | Risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer |
title_sort | risk factors for pulmonary infection after diagnostic bronchoscopy in patients with lung cancer |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103861/ https://www.ncbi.nlm.nih.gov/pubmed/32273634 http://dx.doi.org/10.18999/nagjms.82.1.69 |
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