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Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device
We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the ca...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nagoya University
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103868/ https://www.ncbi.nlm.nih.gov/pubmed/32273641 http://dx.doi.org/10.18999/nagjms.82.1.129 |
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| author | Hiraiwa, Hiroaki Okumura, Takahiro Shimizu, Shinya Arao, Yoshihito Oishi, Hideo Kato, Hiroo Kuwayama, Tasuku Yamaguchi, Shogo Haga, Tomoaki Yokoi, Tsuyoshi Kondo, Toru Sugiura, Yuki Kano, Naoaki Watanabe, Naoki Fukaya, Kenji Furusawa, Kenji Sawamura, Akinori Morimoto, Ryota Fujimoto, Kazuro Mutsuga, Masato Usui, Akihiko Murohara, Toyoaki |
| author_facet | Hiraiwa, Hiroaki Okumura, Takahiro Shimizu, Shinya Arao, Yoshihito Oishi, Hideo Kato, Hiroo Kuwayama, Tasuku Yamaguchi, Shogo Haga, Tomoaki Yokoi, Tsuyoshi Kondo, Toru Sugiura, Yuki Kano, Naoaki Watanabe, Naoki Fukaya, Kenji Furusawa, Kenji Sawamura, Akinori Morimoto, Ryota Fujimoto, Kazuro Mutsuga, Masato Usui, Akihiko Murohara, Toyoaki |
| author_sort | Hiraiwa, Hiroaki |
| collection | PubMed |
| description | We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation. |
| format | Online Article Text |
| id | pubmed-7103868 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nagoya University |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71038682020-04-09 Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device Hiraiwa, Hiroaki Okumura, Takahiro Shimizu, Shinya Arao, Yoshihito Oishi, Hideo Kato, Hiroo Kuwayama, Tasuku Yamaguchi, Shogo Haga, Tomoaki Yokoi, Tsuyoshi Kondo, Toru Sugiura, Yuki Kano, Naoaki Watanabe, Naoki Fukaya, Kenji Furusawa, Kenji Sawamura, Akinori Morimoto, Ryota Fujimoto, Kazuro Mutsuga, Masato Usui, Akihiko Murohara, Toyoaki Nagoya J Med Sci Case Report We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation. Nagoya University 2020-02 /pmc/articles/PMC7103868/ /pubmed/32273641 http://dx.doi.org/10.18999/nagjms.82.1.129 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Case Report Hiraiwa, Hiroaki Okumura, Takahiro Shimizu, Shinya Arao, Yoshihito Oishi, Hideo Kato, Hiroo Kuwayama, Tasuku Yamaguchi, Shogo Haga, Tomoaki Yokoi, Tsuyoshi Kondo, Toru Sugiura, Yuki Kano, Naoaki Watanabe, Naoki Fukaya, Kenji Furusawa, Kenji Sawamura, Akinori Morimoto, Ryota Fujimoto, Kazuro Mutsuga, Masato Usui, Akihiko Murohara, Toyoaki Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device |
| title | Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device |
| title_full | Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device |
| title_fullStr | Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device |
| title_full_unstemmed | Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device |
| title_short | Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device |
| title_sort | pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103868/ https://www.ncbi.nlm.nih.gov/pubmed/32273641 http://dx.doi.org/10.18999/nagjms.82.1.129 |
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