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A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis
We aimed to show the differentiation of the degree and distribution on Fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between patients with immunoglobulin G4-related disease (IgG4-RD) and sarcoidosis, though both diseases frequently show bilateral hilar lymphadenopathy (BHL)....
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nagoya University
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103870/ https://www.ncbi.nlm.nih.gov/pubmed/32273638 http://dx.doi.org/10.18999/nagjms.82.1.101 |
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author | Ozawa, Yoko Yamamoto, Hiroshi Yasuo, Masanori Komatsu, Masamichi Ushiki, Atsuhito Hamano, Hideaki Uehara, Takeshi Kawakami, Satoshi Fujita, Akira Fujinaga, Yasunari Oguchi, Kazuhiro Kawa, Shigeyuki Hanaoka, Masayuki |
author_facet | Ozawa, Yoko Yamamoto, Hiroshi Yasuo, Masanori Komatsu, Masamichi Ushiki, Atsuhito Hamano, Hideaki Uehara, Takeshi Kawakami, Satoshi Fujita, Akira Fujinaga, Yasunari Oguchi, Kazuhiro Kawa, Shigeyuki Hanaoka, Masayuki |
author_sort | Ozawa, Yoko |
collection | PubMed |
description | We aimed to show the differentiation of the degree and distribution on Fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between patients with immunoglobulin G4-related disease (IgG4-RD) and sarcoidosis, though both diseases frequently show bilateral hilar lymphadenopathy (BHL). The clinical records were retrospectively reviewed in 25 patients with IgG4-RD with BHL and 15 patients with sarcoidosis (stage I–II) diagnosed at Shinshu University Hospital. All patients underwent FDG-PET at Aizawa Hospital from January 2004 to December 2015. The FDG accumulation pattern and maximum standardized uptake value (SUVmax) of the hilar lymph nodes were compared between the two groups. The IgG4-RD group (21 men; median age 69 years) showed a significant male predominance and older age compared with the sarcoidosis group (3 men, median age 55.4 years). The IgG4-RD group showed a significantly higher incidence of FDG accumulation in the lachrymal gland, submandibular gland, pancreas, prostate and periurethral and periarterial regions compared with the sarcoidosis group. In contrast, the sarcoidosis group showed a significantly higher incidence of FDG accumulation in the supraclavicular and abdominal lymph nodes, muscle and soft tissues compared with the IgG4-RD group. Furthermore, the SUVmax of the hilar lymph nodes was significantly higher in the sarcoidosis group (median 7.20) than in the IgG4-RD group (median 4.20, p=0.002). In conclusion, significant differences were observed in the FDG accumulation patterns and SUVmax values of the hilar lymph nodes between IgG4-RD with BHL and sarcoidosis, although both diseases develop through the lymphatic routes of the lungs and are frequently associated with BHL. |
format | Online Article Text |
id | pubmed-7103870 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nagoya University |
record_format | MEDLINE/PubMed |
spelling | pubmed-71038702020-04-09 A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis Ozawa, Yoko Yamamoto, Hiroshi Yasuo, Masanori Komatsu, Masamichi Ushiki, Atsuhito Hamano, Hideaki Uehara, Takeshi Kawakami, Satoshi Fujita, Akira Fujinaga, Yasunari Oguchi, Kazuhiro Kawa, Shigeyuki Hanaoka, Masayuki Nagoya J Med Sci Original Paper We aimed to show the differentiation of the degree and distribution on Fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between patients with immunoglobulin G4-related disease (IgG4-RD) and sarcoidosis, though both diseases frequently show bilateral hilar lymphadenopathy (BHL). The clinical records were retrospectively reviewed in 25 patients with IgG4-RD with BHL and 15 patients with sarcoidosis (stage I–II) diagnosed at Shinshu University Hospital. All patients underwent FDG-PET at Aizawa Hospital from January 2004 to December 2015. The FDG accumulation pattern and maximum standardized uptake value (SUVmax) of the hilar lymph nodes were compared between the two groups. The IgG4-RD group (21 men; median age 69 years) showed a significant male predominance and older age compared with the sarcoidosis group (3 men, median age 55.4 years). The IgG4-RD group showed a significantly higher incidence of FDG accumulation in the lachrymal gland, submandibular gland, pancreas, prostate and periurethral and periarterial regions compared with the sarcoidosis group. In contrast, the sarcoidosis group showed a significantly higher incidence of FDG accumulation in the supraclavicular and abdominal lymph nodes, muscle and soft tissues compared with the IgG4-RD group. Furthermore, the SUVmax of the hilar lymph nodes was significantly higher in the sarcoidosis group (median 7.20) than in the IgG4-RD group (median 4.20, p=0.002). In conclusion, significant differences were observed in the FDG accumulation patterns and SUVmax values of the hilar lymph nodes between IgG4-RD with BHL and sarcoidosis, although both diseases develop through the lymphatic routes of the lungs and are frequently associated with BHL. Nagoya University 2020-02 /pmc/articles/PMC7103870/ /pubmed/32273638 http://dx.doi.org/10.18999/nagjms.82.1.101 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Paper Ozawa, Yoko Yamamoto, Hiroshi Yasuo, Masanori Komatsu, Masamichi Ushiki, Atsuhito Hamano, Hideaki Uehara, Takeshi Kawakami, Satoshi Fujita, Akira Fujinaga, Yasunari Oguchi, Kazuhiro Kawa, Shigeyuki Hanaoka, Masayuki A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis |
title | A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis |
title_full | A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis |
title_fullStr | A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis |
title_full_unstemmed | A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis |
title_short | A comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET) between IgG4-related disease with bilateral hilar lymphadenopathy and sarcoidosis |
title_sort | comparison of the features of fluorine-18 fluorodeoxyglucose-positron emission tomography (fdg-pet) between igg4-related disease with bilateral hilar lymphadenopathy and sarcoidosis |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103870/ https://www.ncbi.nlm.nih.gov/pubmed/32273638 http://dx.doi.org/10.18999/nagjms.82.1.101 |
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