Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning

Inositol polyphosphate multikinase (IPMK) is required for the biosynthesis of inositol phosphates (IPs) through the phosphorylation of multiple IP metabolites such as IP3 and IP4. The biological significance of IPMK’s catalytic actions to regulate cellular signaling events such as growth and metabol...

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Detalles Bibliográficos
Autores principales: Lee, Boah, Park, Seung Ju, Lee, Seulgi, Park, Seung Eun, Lee, Eunhye, Song, Ji-Joon, Byun, Youngjoo, Kim, Seyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2020
Materias:
Rapid Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103885/
https://www.ncbi.nlm.nih.gov/pubmed/32209735
http://dx.doi.org/10.14348/molcells.2020.0051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103885/
https://www.ncbi.nlm.nih.gov/pubmed/32209735
http://dx.doi.org/10.14348/molcells.2020.0051

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