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Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders
Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Molecular and Cellular Biology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103888/ https://www.ncbi.nlm.nih.gov/pubmed/32133826 http://dx.doi.org/10.14348/molcells.2020.2289 |
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author | Das, Soumyadip Ramakrishna, Suresh Kim, Kye-Seong |
author_facet | Das, Soumyadip Ramakrishna, Suresh Kim, Kye-Seong |
author_sort | Das, Soumyadip |
collection | PubMed |
description | Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity, axonal growth, and proper function of the nervous system. Moreover, mutations or downregulation of certain DUBs have been found in several neurodegenerative diseases, as well as gliomas and neuroblastomas. Based on emerging findings, DUBs represent an important target for therapeutic intervention in various neurological disorders. Here, we summarize advances in our understanding of the roles of DUBs related to neurobiology. |
format | Online Article Text |
id | pubmed-7103888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-71038882020-04-07 Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders Das, Soumyadip Ramakrishna, Suresh Kim, Kye-Seong Mol Cells Minireview Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity, axonal growth, and proper function of the nervous system. Moreover, mutations or downregulation of certain DUBs have been found in several neurodegenerative diseases, as well as gliomas and neuroblastomas. Based on emerging findings, DUBs represent an important target for therapeutic intervention in various neurological disorders. Here, we summarize advances in our understanding of the roles of DUBs related to neurobiology. Korean Society for Molecular and Cellular Biology 2020-03-31 2020-03-05 /pmc/articles/PMC7103888/ /pubmed/32133826 http://dx.doi.org/10.14348/molcells.2020.2289 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Minireview Das, Soumyadip Ramakrishna, Suresh Kim, Kye-Seong Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders |
title | Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders |
title_full | Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders |
title_fullStr | Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders |
title_full_unstemmed | Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders |
title_short | Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders |
title_sort | critical roles of deubiquitinating enzymes in the nervous system and neurodegenerative disorders |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103888/ https://www.ncbi.nlm.nih.gov/pubmed/32133826 http://dx.doi.org/10.14348/molcells.2020.2289 |
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