Novel Diubiquitin Probes Expand the Chemical Toolkit to Study DUBs

Linkage-specific DUBs employ different mechanisms to recognize and cleave polyubiquitin chains of specific linkage types. In this issue of Cell Chemical Biology, Flierman et al. (2016) develop a new family of novel non-hydrolyzable diubiquitin probes that will be valuable tools to study how DUBs ach...

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Detalles Bibliográficos
Autor principal: Kulathu, Yogesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104002/
https://www.ncbi.nlm.nih.gov/pubmed/27105279
http://dx.doi.org/10.1016/j.chembiol.2016.04.001
Descripción
Sumario:Linkage-specific DUBs employ different mechanisms to recognize and cleave polyubiquitin chains of specific linkage types. In this issue of Cell Chemical Biology, Flierman et al. (2016) develop a new family of novel non-hydrolyzable diubiquitin probes that will be valuable tools to study how DUBs achieve specificity.

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