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Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) define medical conditions of acute respiratory insufficiency deriving from direct and indirect damage of the alveolar parenchyma and often associated with multiorgan dysfunction (MODS). As a rule, intensive care is based on mecha...

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Autor principal: Hans-Peter, Kapfhammer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D. Steinkopff-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104133/
https://www.ncbi.nlm.nih.gov/pubmed/32288847
http://dx.doi.org/10.1007/s11800-008-0129-x
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author Hans-Peter, Kapfhammer
author_facet Hans-Peter, Kapfhammer
author_sort Hans-Peter, Kapfhammer
collection PubMed
description Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) define medical conditions of acute respiratory insufficiency deriving from direct and indirect damage of the alveolar parenchyma and often associated with multiorgan dysfunction (MODS). As a rule, intensive care is based on mechanical ventilation often requiring high doses of sedatives and narcotics. Despite major progress in intensive care medicine the rate of mortality is still very high. Whereas in the past the level of medical progress has been rated based on the mortality rate alone, the many negative somatic and psychological sequelae in long-term-survivors of ARDS are only now being appreciated. From a perspective of C/L psychiatry persisting cognitive dysfunctions, anxiety and mood disorders, posttraumatic stress disorders (PTSD) in their negative impact on health-related quality of life are intensively investigated. In the etiopathogenesis of PTSD associated with ALI/ARDS, many influences have to be discussed, e.g., increases in CO(2) triggering panic affects, a mismatch of norepinephric overstimulation and cortisol insufficiency, negative effects of high doses of benzodiazepines resulting in oversedation, prolonged phases of weaning and more frequent states of delirium. Consolidation and retrieval of traumatic memories of the ICU stay are influenced by complex factors. From a clinical point of view prophylactic stress doses of hydrocortisone may reduce the major risk of PTSD associated with ALI / ARDS.
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spelling pubmed-71041332020-03-31 Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock Hans-Peter, Kapfhammer Psychosom Konsiliarpsychiatr Übersicht Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) define medical conditions of acute respiratory insufficiency deriving from direct and indirect damage of the alveolar parenchyma and often associated with multiorgan dysfunction (MODS). As a rule, intensive care is based on mechanical ventilation often requiring high doses of sedatives and narcotics. Despite major progress in intensive care medicine the rate of mortality is still very high. Whereas in the past the level of medical progress has been rated based on the mortality rate alone, the many negative somatic and psychological sequelae in long-term-survivors of ARDS are only now being appreciated. From a perspective of C/L psychiatry persisting cognitive dysfunctions, anxiety and mood disorders, posttraumatic stress disorders (PTSD) in their negative impact on health-related quality of life are intensively investigated. In the etiopathogenesis of PTSD associated with ALI/ARDS, many influences have to be discussed, e.g., increases in CO(2) triggering panic affects, a mismatch of norepinephric overstimulation and cortisol insufficiency, negative effects of high doses of benzodiazepines resulting in oversedation, prolonged phases of weaning and more frequent states of delirium. Consolidation and retrieval of traumatic memories of the ICU stay are influenced by complex factors. From a clinical point of view prophylactic stress doses of hydrocortisone may reduce the major risk of PTSD associated with ALI / ARDS. D. Steinkopff-Verlag 2008-11-27 2008 /pmc/articles/PMC7104133/ /pubmed/32288847 http://dx.doi.org/10.1007/s11800-008-0129-x Text en © Springer Medizin Verlag GmbH. 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Übersicht
Hans-Peter, Kapfhammer
Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock
title Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock
title_full Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock
title_fullStr Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock
title_full_unstemmed Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock
title_short Posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ARDS) and septic shock
title_sort posttraumatic stress disorder in survivors of acute respiratory distress syndrome (ards) and septic shock
topic Übersicht
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104133/
https://www.ncbi.nlm.nih.gov/pubmed/32288847
http://dx.doi.org/10.1007/s11800-008-0129-x
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