Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide

Synthesis of amino acid conjugates of glycyrrhizic acid with the use of N-hydroxyphthalimide, N,N'-dicyclohexylcarbodiimide, and tert-butyl esters of L-amino acids (valine, isoleucine, phenylalanine, and methionine) was performed followed by deprotection with trifluoroacetic acid. The target am...

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Detalles Bibliográficos
Autores principales: Baltina, L. A., Fairushina, A. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104134/
https://www.ncbi.nlm.nih.gov/pubmed/32288467
http://dx.doi.org/10.1134/S1070363215120129
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author Baltina, L. A.
Fairushina, A. I.
Baltina, L. A.
author_facet Baltina, L. A.
Fairushina, A. I.
Baltina, L. A.
author_sort Baltina, L. A.
collection PubMed
description Synthesis of amino acid conjugates of glycyrrhizic acid with the use of N-hydroxyphthalimide, N,N'-dicyclohexylcarbodiimide, and tert-butyl esters of L-amino acids (valine, isoleucine, phenylalanine, and methionine) was performed followed by deprotection with trifluoroacetic acid. The target amino acid conjugates were isolated by column chromatography on silica gel in 40–45% yield. The structure of the prepared compounds was confirmed by IR and (13)C NMR spectroscopy.
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spelling pubmed-71041342020-03-31 Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide Baltina, L. A. Fairushina, A. I. Baltina, L. A. Russ J Gen Chem Article Synthesis of amino acid conjugates of glycyrrhizic acid with the use of N-hydroxyphthalimide, N,N'-dicyclohexylcarbodiimide, and tert-butyl esters of L-amino acids (valine, isoleucine, phenylalanine, and methionine) was performed followed by deprotection with trifluoroacetic acid. The target amino acid conjugates were isolated by column chromatography on silica gel in 40–45% yield. The structure of the prepared compounds was confirmed by IR and (13)C NMR spectroscopy. Pleiades Publishing 2016-02-06 2015 /pmc/articles/PMC7104134/ /pubmed/32288467 http://dx.doi.org/10.1134/S1070363215120129 Text en © Pleiades Publishing, Ltd. 2015 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Baltina, L. A.
Fairushina, A. I.
Baltina, L. A.
Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide
title Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide
title_full Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide
title_fullStr Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide
title_full_unstemmed Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide
title_short Synthesis of amino acid conjugates of glycyrrhizic acid using N-hydroxyphthalimide and N,N'-dicyclohexylcarbodiimide
title_sort synthesis of amino acid conjugates of glycyrrhizic acid using n-hydroxyphthalimide and n,n'-dicyclohexylcarbodiimide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104134/
https://www.ncbi.nlm.nih.gov/pubmed/32288467
http://dx.doi.org/10.1134/S1070363215120129
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