Exploring histone loading on HIV DNA reveals a dynamic nucleosome positioning between unintegrated and integrated viral genome

The aim of the present study was to understand the biology of unintegrated HIV-1 DNA and reveal the mechanisms involved in its transcriptional silencing. We found that histones are loaded on HIV-1 DNA after its nuclear import and before its integration in the host genome. Nucleosome positioning anal...

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Detalles Bibliográficos
Autores principales: Machida, Shinichi, Depierre, David, Chen, Heng-Chang, Thenin-Houssier, Suzie, Petitjean, Gaël, Doyen, Cecile M., Takaku, Motoki, Cuvier, Olivier, Benkirane, Monsef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104181/
https://www.ncbi.nlm.nih.gov/pubmed/32161134
http://dx.doi.org/10.1073/pnas.1913754117

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