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Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes

Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block CRISPR-Cas-mediated genome editing in eukaryotic...

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Detalles Bibliográficos
Autores principales:	Watters, Kyle E., Shivram, Haridha, Fellmann, Christof, Lew, Rachel J., McMahon, Blake, Doudna, Jennifer A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104187/ https://www.ncbi.nlm.nih.gov/pubmed/32156733 http://dx.doi.org/10.1073/pnas.1917668117

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