Coombs-positive Paroxysmal Nocturnal Haemoglobinuria

Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies. The direct antiglobulin test (DAT) or Coombs test...

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Autores principales: Kalam, Sabrina, Beale, Rupert, Hughes, Derralynn, Kulasekararaj, Austin, Srirangalingam, Umasuthan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104188/
https://www.ncbi.nlm.nih.gov/pubmed/32257252
http://dx.doi.org/10.1093/omcr/omz125
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author Kalam, Sabrina
Beale, Rupert
Hughes, Derralynn
Kulasekararaj, Austin
Srirangalingam, Umasuthan
author_facet Kalam, Sabrina
Beale, Rupert
Hughes, Derralynn
Kulasekararaj, Austin
Srirangalingam, Umasuthan
author_sort Kalam, Sabrina
collection PubMed
description Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies. The direct antiglobulin test (DAT) or Coombs test is positive in cases of immune-mediated haemolytic anaemia and, thus, is positive in AIHA but negative in PNH. We report a case of a woman presenting with a haemolytic anaemia who was found to have concomitant evidence of AIHA and PNH. The case highlights the importance of carrying out a comprehensive haemolysis work-up in patients who present with haemolytic anaemia.
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spelling pubmed-71041882020-04-03 Coombs-positive Paroxysmal Nocturnal Haemoglobinuria Kalam, Sabrina Beale, Rupert Hughes, Derralynn Kulasekararaj, Austin Srirangalingam, Umasuthan Oxf Med Case Reports Case Report Autoimmune haemolytic anaemia (AIHA) and paroxysmal nocturnal haemoglobinuria (PNH) are two distinct causes of haemolytic anaemia. They have different mechanisms that underpin their pathogenesis and, therefore, require different treatment strategies. The direct antiglobulin test (DAT) or Coombs test is positive in cases of immune-mediated haemolytic anaemia and, thus, is positive in AIHA but negative in PNH. We report a case of a woman presenting with a haemolytic anaemia who was found to have concomitant evidence of AIHA and PNH. The case highlights the importance of carrying out a comprehensive haemolysis work-up in patients who present with haemolytic anaemia. Oxford University Press 2020-03-30 /pmc/articles/PMC7104188/ /pubmed/32257252 http://dx.doi.org/10.1093/omcr/omz125 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Kalam, Sabrina
Beale, Rupert
Hughes, Derralynn
Kulasekararaj, Austin
Srirangalingam, Umasuthan
Coombs-positive Paroxysmal Nocturnal Haemoglobinuria
title Coombs-positive Paroxysmal Nocturnal Haemoglobinuria
title_full Coombs-positive Paroxysmal Nocturnal Haemoglobinuria
title_fullStr Coombs-positive Paroxysmal Nocturnal Haemoglobinuria
title_full_unstemmed Coombs-positive Paroxysmal Nocturnal Haemoglobinuria
title_short Coombs-positive Paroxysmal Nocturnal Haemoglobinuria
title_sort coombs-positive paroxysmal nocturnal haemoglobinuria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104188/
https://www.ncbi.nlm.nih.gov/pubmed/32257252
http://dx.doi.org/10.1093/omcr/omz125
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