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aPKC in neuronal differentiation, maturation and function

The atypical Protein Kinase Cs (aPKCs)—PRKCI, PRKCZ and PKMζ—form a subfamily within the Protein Kinase C (PKC) family. These kinases are expressed in the nervous system, including during its development and in adulthood. One of the aPKCs, PKMζ, appears to be restricted to the nervous system. aPKCs...

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Detalles Bibliográficos
Autores principales: Hapak, Sophie M., Rothlin, Carla V., Ghosh, Sourav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104321/
https://www.ncbi.nlm.nih.gov/pubmed/32269838
http://dx.doi.org/10.1042/NS20190019
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author Hapak, Sophie M.
Rothlin, Carla V.
Ghosh, Sourav
author_facet Hapak, Sophie M.
Rothlin, Carla V.
Ghosh, Sourav
author_sort Hapak, Sophie M.
collection PubMed
description The atypical Protein Kinase Cs (aPKCs)—PRKCI, PRKCZ and PKMζ—form a subfamily within the Protein Kinase C (PKC) family. These kinases are expressed in the nervous system, including during its development and in adulthood. One of the aPKCs, PKMζ, appears to be restricted to the nervous system. aPKCs are known to play a role in a variety of cellular responses such as proliferation, differentiation, polarity, migration, survival and key metabolic functions such as glucose uptake, that are critical for nervous system development and function. Therefore, these kinases have garnered a lot of interest in terms of their functional role in the nervous system. Here we review the expression and function of aPKCs in neural development and in neuronal maturation and function. Despite seemingly paradoxical findings with genetic deletion versus gene silencing approaches, we posit that aPKCs are likely candidates for regulating many important neurodevelopmental and neuronal functions, and may be associated with a number of human neuropsychiatric diseases.
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spelling pubmed-71043212020-04-06 aPKC in neuronal differentiation, maturation and function Hapak, Sophie M. Rothlin, Carla V. Ghosh, Sourav Neuronal Signal Neuroscience The atypical Protein Kinase Cs (aPKCs)—PRKCI, PRKCZ and PKMζ—form a subfamily within the Protein Kinase C (PKC) family. These kinases are expressed in the nervous system, including during its development and in adulthood. One of the aPKCs, PKMζ, appears to be restricted to the nervous system. aPKCs are known to play a role in a variety of cellular responses such as proliferation, differentiation, polarity, migration, survival and key metabolic functions such as glucose uptake, that are critical for nervous system development and function. Therefore, these kinases have garnered a lot of interest in terms of their functional role in the nervous system. Here we review the expression and function of aPKCs in neural development and in neuronal maturation and function. Despite seemingly paradoxical findings with genetic deletion versus gene silencing approaches, we posit that aPKCs are likely candidates for regulating many important neurodevelopmental and neuronal functions, and may be associated with a number of human neuropsychiatric diseases. Portland Press Ltd. 2019-09-23 /pmc/articles/PMC7104321/ /pubmed/32269838 http://dx.doi.org/10.1042/NS20190019 Text en © 2019 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Neuroscience
Hapak, Sophie M.
Rothlin, Carla V.
Ghosh, Sourav
aPKC in neuronal differentiation, maturation and function
title aPKC in neuronal differentiation, maturation and function
title_full aPKC in neuronal differentiation, maturation and function
title_fullStr aPKC in neuronal differentiation, maturation and function
title_full_unstemmed aPKC in neuronal differentiation, maturation and function
title_short aPKC in neuronal differentiation, maturation and function
title_sort apkc in neuronal differentiation, maturation and function
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104321/
https://www.ncbi.nlm.nih.gov/pubmed/32269838
http://dx.doi.org/10.1042/NS20190019
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