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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

The anti-cancer drug target poly(ADP-ribose) polymerase 1 (PARP1) and its close homologue, PARP2, are early responders to DNA damage in human cells(1,2). Upon binding to genomic lesions, these enzymes utilise NAD(+) to modify a plethora of proteins with mono- and poly(ADP-ribose) signals that are im...

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Detalles Bibliográficos
Autores principales:	Suskiewicz, Marcin J., Zobel, Florian, Ogden, Tom E. H., Fontana, Pietro, Ariza, Antonio, Yang, Ji-Chun, Zhu, Kang, Bracken, Lily, Hawthorne, William J., Ahel, Dragana, Neuhaus, David, Ahel, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104379/ https://www.ncbi.nlm.nih.gov/pubmed/32028527 http://dx.doi.org/10.1038/s41586-020-2013-6

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