Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology

A type of chromosome-free cell called SimCells (simple cells) has been generated from Escherichia coli, Pseudomonas putida, and Ralstonia eutropha. The removal of the native chromosomes of these bacteria was achieved by double-stranded breaks made by heterologous I-CeuI endonuclease and the degradat...

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Detalles Bibliográficos
Autores principales: Fan, Catherine, Davison, Paul A., Habgood, Robert, Zeng, Hong, Decker, Christoph M., Gesell Salazar, Manuela, Lueangwattanapong, Khemmathin, Townley, Helen E., Yang, Aidong, Thompson, Ian P., Ye, Hua, Cui, Zhanfeng, Schmidt, Frank, Hunter, C. Neil, Huang, Wei E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104398/
https://www.ncbi.nlm.nih.gov/pubmed/32144140
http://dx.doi.org/10.1073/pnas.1918859117

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