Intracellular and extracellular serpins modulate lung disease

An imbalance between peptidases and their inhibitors leads to pulmonary disease. Imbalances occur in the adult and the neonate at risk for a specific set of lung pathologies. Serpins (serine peptidase inhibitors) make up the major source of antipeptidase activity in the lung. The purpose of this rev...

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Detalles Bibliográficos
Autores principales: Askew, D J, Silverman, G A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104463/
https://www.ncbi.nlm.nih.gov/pubmed/19057604
http://dx.doi.org/10.1038/jp.2008.150
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author Askew, D J
Silverman, G A
author_facet Askew, D J
Silverman, G A
author_sort Askew, D J
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description An imbalance between peptidases and their inhibitors leads to pulmonary disease. Imbalances occur in the adult and the neonate at risk for a specific set of lung pathologies. Serpins (serine peptidase inhibitors) make up the major source of antipeptidase activity in the lung. The purpose of this review is to describe the serpin mechanism of inhibition, their roles in the normal and pathological lung and their potential as therapeutic agents.
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spelling pubmed-71044632020-03-31 Intracellular and extracellular serpins modulate lung disease Askew, D J Silverman, G A J Perinatol Article An imbalance between peptidases and their inhibitors leads to pulmonary disease. Imbalances occur in the adult and the neonate at risk for a specific set of lung pathologies. Serpins (serine peptidase inhibitors) make up the major source of antipeptidase activity in the lung. The purpose of this review is to describe the serpin mechanism of inhibition, their roles in the normal and pathological lung and their potential as therapeutic agents. Nature Publishing Group US 2008-12-05 2008 /pmc/articles/PMC7104463/ /pubmed/19057604 http://dx.doi.org/10.1038/jp.2008.150 Text en © Nature Publishing Group 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Askew, D J
Silverman, G A
Intracellular and extracellular serpins modulate lung disease
title Intracellular and extracellular serpins modulate lung disease
title_full Intracellular and extracellular serpins modulate lung disease
title_fullStr Intracellular and extracellular serpins modulate lung disease
title_full_unstemmed Intracellular and extracellular serpins modulate lung disease
title_short Intracellular and extracellular serpins modulate lung disease
title_sort intracellular and extracellular serpins modulate lung disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104463/
https://www.ncbi.nlm.nih.gov/pubmed/19057604
http://dx.doi.org/10.1038/jp.2008.150
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