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Integrins in multiple myeloma
Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions in MM cells, and therefore are potential therapeutic targets. We have recently shown that in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104491/ https://www.ncbi.nlm.nih.gov/pubmed/32256871 http://dx.doi.org/10.1186/s41232-020-00113-y |
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author | Hosen, Naoki |
author_facet | Hosen, Naoki |
author_sort | Hosen, Naoki |
collection | PubMed |
description | Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions in MM cells, and therefore are potential therapeutic targets. We have recently shown that integrin β7 constitutively adopts the active conformation specifically in MM cells, and found that chimeric antigen receptor (CAR) T cells targeting the activated conformation of integrin β7 is promising for MM. Although the mechanism for the constitutive activation is still being investigated, our results indicate that integrin conformation is different between MM and normal cells and suggest that it may be associated with the pathology of MM. |
format | Online Article Text |
id | pubmed-7104491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71044912020-04-01 Integrins in multiple myeloma Hosen, Naoki Inflamm Regen Review Integrins have crucial roles in BM homing, survival, proliferation, or drug resistance of multiple myeloma (MM) cells. Especially, integrin α4β1 (VLA-4) and α4β7 has been reported to have important functions in MM cells, and therefore are potential therapeutic targets. We have recently shown that integrin β7 constitutively adopts the active conformation specifically in MM cells, and found that chimeric antigen receptor (CAR) T cells targeting the activated conformation of integrin β7 is promising for MM. Although the mechanism for the constitutive activation is still being investigated, our results indicate that integrin conformation is different between MM and normal cells and suggest that it may be associated with the pathology of MM. BioMed Central 2020-03-30 /pmc/articles/PMC7104491/ /pubmed/32256871 http://dx.doi.org/10.1186/s41232-020-00113-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Hosen, Naoki Integrins in multiple myeloma |
title | Integrins in multiple myeloma |
title_full | Integrins in multiple myeloma |
title_fullStr | Integrins in multiple myeloma |
title_full_unstemmed | Integrins in multiple myeloma |
title_short | Integrins in multiple myeloma |
title_sort | integrins in multiple myeloma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104491/ https://www.ncbi.nlm.nih.gov/pubmed/32256871 http://dx.doi.org/10.1186/s41232-020-00113-y |
work_keys_str_mv | AT hosennaoki integrinsinmultiplemyeloma |