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Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review
BACKGROUND: Hepatic angiosarcoma is a rare malignant tumor featured by highly aggressive behavior and poor prognosis. There are few reports about diffused hepatic angiosarcoma with Kasabach-Merritt syndrome till now. CASE PRESENTATION: A male patient with the chief complain of hepatic space-occupyin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104501/ https://www.ncbi.nlm.nih.gov/pubmed/32228471 http://dx.doi.org/10.1186/s12876-020-01216-z |
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author | Zhang, Xing-mao Tong, Yao Li, Qing He, Qiang |
author_facet | Zhang, Xing-mao Tong, Yao Li, Qing He, Qiang |
author_sort | Zhang, Xing-mao |
collection | PubMed |
description | BACKGROUND: Hepatic angiosarcoma is a rare malignant tumor featured by highly aggressive behavior and poor prognosis. There are few reports about diffused hepatic angiosarcoma with Kasabach-Merritt syndrome till now. CASE PRESENTATION: A male patient with the chief complain of hepatic space-occupying lesion accompanied by disturbance of consciousness and jaundice. Hyperbilirubinemia, anemia, thrombocytopenia, prolonged prothrombin time, hypofibrinogenemia, decreased prothrombin activity, and increased fibrinogen degradation product and D-dimer were confirmed by blood analysis; multiple focal hypodense lesions in liver was detected by abdominal computed tomography. Liver failure and Kasabach-Merritt syndrome induced by hepatic hemangioma was diagnosed before operation and liver transplantation was performed. Hepatic angiosarcoma was finally proven by postoperative pathology. This patient died of tumor metastasis 2 months after operation. CONCLUSIONS: Hepatic angiosarcoma which can generate Kasabach-Merritt syndrome and even liver failure has an extremely poor prognosis; liver transplantation option should not be considered in hepatic angiosarcoma regardless of the reason. |
format | Online Article Text |
id | pubmed-7104501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71045012020-03-31 Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review Zhang, Xing-mao Tong, Yao Li, Qing He, Qiang BMC Gastroenterol Case Report BACKGROUND: Hepatic angiosarcoma is a rare malignant tumor featured by highly aggressive behavior and poor prognosis. There are few reports about diffused hepatic angiosarcoma with Kasabach-Merritt syndrome till now. CASE PRESENTATION: A male patient with the chief complain of hepatic space-occupying lesion accompanied by disturbance of consciousness and jaundice. Hyperbilirubinemia, anemia, thrombocytopenia, prolonged prothrombin time, hypofibrinogenemia, decreased prothrombin activity, and increased fibrinogen degradation product and D-dimer were confirmed by blood analysis; multiple focal hypodense lesions in liver was detected by abdominal computed tomography. Liver failure and Kasabach-Merritt syndrome induced by hepatic hemangioma was diagnosed before operation and liver transplantation was performed. Hepatic angiosarcoma was finally proven by postoperative pathology. This patient died of tumor metastasis 2 months after operation. CONCLUSIONS: Hepatic angiosarcoma which can generate Kasabach-Merritt syndrome and even liver failure has an extremely poor prognosis; liver transplantation option should not be considered in hepatic angiosarcoma regardless of the reason. BioMed Central 2020-03-30 /pmc/articles/PMC7104501/ /pubmed/32228471 http://dx.doi.org/10.1186/s12876-020-01216-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Zhang, Xing-mao Tong, Yao Li, Qing He, Qiang Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review |
title | Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review |
title_full | Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review |
title_fullStr | Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review |
title_full_unstemmed | Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review |
title_short | Diffused hepatic angiosarcoma with Kasabach-Merritt syndrome-case report and literature review |
title_sort | diffused hepatic angiosarcoma with kasabach-merritt syndrome-case report and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104501/ https://www.ncbi.nlm.nih.gov/pubmed/32228471 http://dx.doi.org/10.1186/s12876-020-01216-z |
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