Enzyme replacement therapy in mice lacking arylsulfatase B targets bone-remodeling cells, but not chondrocytes

Mucopolysaccharidosis type VI (MPS-VI), caused by mutational inactivation of the glycosaminoglycan-degrading enzyme arylsulfatase B (Arsb), is a lysosomal storage disorder primarily affecting the skeleton. We have previously reported that Arsb-deficient mice display high trabecular bone mass and imp...

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Detalles Bibliográficos
Autores principales: Hendrickx, Gretl, Danyukova, Tatyana, Baranowsky, Anke, Rolvien, Tim, Angermann, Alexandra, Schweizer, Michaela, Keller, Johannes, Schröder, Jörg, Meyer-Schwesinger, Catherine, Muschol, Nicole, Paganini, Chiara, Rossi, Antonio, Amling, Michael, Pohl, Sandra, Schinke, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
General Article Two
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104678/
https://www.ncbi.nlm.nih.gov/pubmed/31943020
http://dx.doi.org/10.1093/hmg/ddaa006

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