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Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity

Human beta1-coronavirus (β1CoV) OC43 emerged relatively recently through a single zoonotic introduction. Like related animal β1CoVs, OC43 uses 9-O-acetylated sialic acid as receptor determinant. β1CoV receptor binding is typically controlled by attachment/fusion spike protein S and receptor-binding/...

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Autores principales: Bakkers, Mark J.G., Lang, Yifei, Feitsma, Louris J., Hulswit, Ruben J.G., de Poot, Stefanie A.H., van Vliet, Arno L.W., Margine, Irina, de Groot-Mijnes, Jolanda D.F., van Kuppeveld, Frank J.M., Langereis, Martijn A., Huizinga, Eric G., de Groot, Raoul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104930/
https://www.ncbi.nlm.nih.gov/pubmed/28279346
http://dx.doi.org/10.1016/j.chom.2017.02.008
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author Bakkers, Mark J.G.
Lang, Yifei
Feitsma, Louris J.
Hulswit, Ruben J.G.
de Poot, Stefanie A.H.
van Vliet, Arno L.W.
Margine, Irina
de Groot-Mijnes, Jolanda D.F.
van Kuppeveld, Frank J.M.
Langereis, Martijn A.
Huizinga, Eric G.
de Groot, Raoul J.
author_facet Bakkers, Mark J.G.
Lang, Yifei
Feitsma, Louris J.
Hulswit, Ruben J.G.
de Poot, Stefanie A.H.
van Vliet, Arno L.W.
Margine, Irina
de Groot-Mijnes, Jolanda D.F.
van Kuppeveld, Frank J.M.
Langereis, Martijn A.
Huizinga, Eric G.
de Groot, Raoul J.
author_sort Bakkers, Mark J.G.
collection PubMed
description Human beta1-coronavirus (β1CoV) OC43 emerged relatively recently through a single zoonotic introduction. Like related animal β1CoVs, OC43 uses 9-O-acetylated sialic acid as receptor determinant. β1CoV receptor binding is typically controlled by attachment/fusion spike protein S and receptor-binding/receptor-destroying hemagglutinin-esterase protein HE. We show that following OC43’s introduction into humans, HE-mediated receptor binding was selected against and ultimately lost through progressive accumulation of mutations in the HE lectin domain. Consequently, virion-associated receptor-destroying activity toward multivalent glycoconjugates was reduced and altered such that some clustered receptor populations are no longer cleaved. Loss of HE lectin function was also observed for another respiratory human coronavirus, HKU1. This thus appears to be an adaptation to the sialoglycome of the human respiratory tract and for replication in human airways. The findings suggest that the dynamics of virion-glycan interactions contribute to host tropism. Our observations are relevant also to other human respiratory viruses of zoonotic origin, particularly influenza A virus.
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spelling pubmed-71049302020-03-31 Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity Bakkers, Mark J.G. Lang, Yifei Feitsma, Louris J. Hulswit, Ruben J.G. de Poot, Stefanie A.H. van Vliet, Arno L.W. Margine, Irina de Groot-Mijnes, Jolanda D.F. van Kuppeveld, Frank J.M. Langereis, Martijn A. Huizinga, Eric G. de Groot, Raoul J. Cell Host Microbe Article Human beta1-coronavirus (β1CoV) OC43 emerged relatively recently through a single zoonotic introduction. Like related animal β1CoVs, OC43 uses 9-O-acetylated sialic acid as receptor determinant. β1CoV receptor binding is typically controlled by attachment/fusion spike protein S and receptor-binding/receptor-destroying hemagglutinin-esterase protein HE. We show that following OC43’s introduction into humans, HE-mediated receptor binding was selected against and ultimately lost through progressive accumulation of mutations in the HE lectin domain. Consequently, virion-associated receptor-destroying activity toward multivalent glycoconjugates was reduced and altered such that some clustered receptor populations are no longer cleaved. Loss of HE lectin function was also observed for another respiratory human coronavirus, HKU1. This thus appears to be an adaptation to the sialoglycome of the human respiratory tract and for replication in human airways. The findings suggest that the dynamics of virion-glycan interactions contribute to host tropism. Our observations are relevant also to other human respiratory viruses of zoonotic origin, particularly influenza A virus. Elsevier Inc. 2017-03-08 2017-03-08 /pmc/articles/PMC7104930/ /pubmed/28279346 http://dx.doi.org/10.1016/j.chom.2017.02.008 Text en © 2017 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bakkers, Mark J.G.
Lang, Yifei
Feitsma, Louris J.
Hulswit, Ruben J.G.
de Poot, Stefanie A.H.
van Vliet, Arno L.W.
Margine, Irina
de Groot-Mijnes, Jolanda D.F.
van Kuppeveld, Frank J.M.
Langereis, Martijn A.
Huizinga, Eric G.
de Groot, Raoul J.
Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
title Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
title_full Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
title_fullStr Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
title_full_unstemmed Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
title_short Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity
title_sort betacoronavirus adaptation to humans involved progressive loss of hemagglutinin-esterase lectin activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104930/
https://www.ncbi.nlm.nih.gov/pubmed/28279346
http://dx.doi.org/10.1016/j.chom.2017.02.008
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