Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities

A phytochemical investigation of the ethanol extract of Toona sinensis (A. Juss.) Roem resulted in the isolation of ten new limonoids, toonasinenines A–J (1–10), together with two known compounds, toonafolin (11) and toonacilianin D (12). Their structures were determined by spectroscopic analyses. T...

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Detalles Bibliográficos
Autores principales: Hu, Jiang, Song, Yan, Mao, Xia, Wang, Zhen-Ji, Zhao, Qin-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104945/
https://www.ncbi.nlm.nih.gov/pubmed/32288789
http://dx.doi.org/10.1016/j.jff.2015.10.009
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author Hu, Jiang
Song, Yan
Mao, Xia
Wang, Zhen-Ji
Zhao, Qin-Jie
author_facet Hu, Jiang
Song, Yan
Mao, Xia
Wang, Zhen-Ji
Zhao, Qin-Jie
author_sort Hu, Jiang
collection PubMed
description A phytochemical investigation of the ethanol extract of Toona sinensis (A. Juss.) Roem resulted in the isolation of ten new limonoids, toonasinenines A–J (1–10), together with two known compounds, toonafolin (11) and toonacilianin D (12). Their structures were determined by spectroscopic analyses. The isolated components were evaluated in vitro for radical scavenging potential using ABTS(⋅+) and DPPH test, anti-inflammatory activities for Cox-1 and Cox-2, and cytotoxicies against nine tumour cell lines (A549, BGC-823, CHG-5, HCT15, HeLa, HepG2, MDA-MB-231, SHG-44 and SGC-7901 cells). As a result, 4, 5 and 7–10 showed potent radical scavenging activities, while limonoids 1–4 and 11 exhibited significant anti-inflammatory and cytotoxic potential.
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spelling pubmed-71049452020-03-31 Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities Hu, Jiang Song, Yan Mao, Xia Wang, Zhen-Ji Zhao, Qin-Jie J Funct Foods Article A phytochemical investigation of the ethanol extract of Toona sinensis (A. Juss.) Roem resulted in the isolation of ten new limonoids, toonasinenines A–J (1–10), together with two known compounds, toonafolin (11) and toonacilianin D (12). Their structures were determined by spectroscopic analyses. The isolated components were evaluated in vitro for radical scavenging potential using ABTS(⋅+) and DPPH test, anti-inflammatory activities for Cox-1 and Cox-2, and cytotoxicies against nine tumour cell lines (A549, BGC-823, CHG-5, HCT15, HeLa, HepG2, MDA-MB-231, SHG-44 and SGC-7901 cells). As a result, 4, 5 and 7–10 showed potent radical scavenging activities, while limonoids 1–4 and 11 exhibited significant anti-inflammatory and cytotoxic potential. Elsevier Ltd. 2016-01 2015-11-10 /pmc/articles/PMC7104945/ /pubmed/32288789 http://dx.doi.org/10.1016/j.jff.2015.10.009 Text en Copyright © 2015 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hu, Jiang
Song, Yan
Mao, Xia
Wang, Zhen-Ji
Zhao, Qin-Jie
Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities
title Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities
title_full Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities
title_fullStr Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities
title_full_unstemmed Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities
title_short Limonoids isolated from Toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities
title_sort limonoids isolated from toona sinensis and their radical scavenging, anti-inflammatory and cytotoxic activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104945/
https://www.ncbi.nlm.nih.gov/pubmed/32288789
http://dx.doi.org/10.1016/j.jff.2015.10.009
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