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Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology
Compared to classical epidemiologic methods, genomics can be used to precisely monitor virus evolution and transmission in real time across large, diverse populations. Integration of pathogen genomics with data about host genetics and global transcriptional responses to infection allows for comprehe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104983/ https://www.ncbi.nlm.nih.gov/pubmed/27173929 http://dx.doi.org/10.1016/j.chom.2016.04.016 |
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author | Rasmussen, Angela L. Katze, Michael G. |
author_facet | Rasmussen, Angela L. Katze, Michael G. |
author_sort | Rasmussen, Angela L. |
collection | PubMed |
description | Compared to classical epidemiologic methods, genomics can be used to precisely monitor virus evolution and transmission in real time across large, diverse populations. Integration of pathogen genomics with data about host genetics and global transcriptional responses to infection allows for comprehensive studies of population-level responses to infection and provides novel methods for predicting clinical outcomes. As genomic technologies become more accessible, these methods will redefine how emerging viruses are studied and outbreaks are contained. Here we review the existing and emerging genomic technologies that are enabling systems epidemiology and systems virology and making it possible to respond rapidly to emerging viruses such as Zika. |
format | Online Article Text |
id | pubmed-7104983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71049832020-03-31 Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology Rasmussen, Angela L. Katze, Michael G. Cell Host Microbe Article Compared to classical epidemiologic methods, genomics can be used to precisely monitor virus evolution and transmission in real time across large, diverse populations. Integration of pathogen genomics with data about host genetics and global transcriptional responses to infection allows for comprehensive studies of population-level responses to infection and provides novel methods for predicting clinical outcomes. As genomic technologies become more accessible, these methods will redefine how emerging viruses are studied and outbreaks are contained. Here we review the existing and emerging genomic technologies that are enabling systems epidemiology and systems virology and making it possible to respond rapidly to emerging viruses such as Zika. Published by Elsevier Inc. 2016-05-11 2016-05-11 /pmc/articles/PMC7104983/ /pubmed/27173929 http://dx.doi.org/10.1016/j.chom.2016.04.016 Text en © 2016 Published by Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Rasmussen, Angela L. Katze, Michael G. Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology |
title | Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology |
title_full | Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology |
title_fullStr | Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology |
title_full_unstemmed | Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology |
title_short | Genomic Signatures of Emerging Viruses: A New Era of Systems Epidemiology |
title_sort | genomic signatures of emerging viruses: a new era of systems epidemiology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104983/ https://www.ncbi.nlm.nih.gov/pubmed/27173929 http://dx.doi.org/10.1016/j.chom.2016.04.016 |
work_keys_str_mv | AT rasmussenangelal genomicsignaturesofemergingvirusesaneweraofsystemsepidemiology AT katzemichaelg genomicsignaturesofemergingvirusesaneweraofsystemsepidemiology |