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Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan

BACKGROUND/PURPOSE: Human coronavirus (HCoV) NL63 is recognized in association with upper or lower respiratory tract illnesses in children. This study surveyed the prevalence of HCoV-NL63 and influenza viruses in patients with influenza-like illness in Taiwan during 2010–2011. METHODS: Throat sample...

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Autores principales: Huang, Su-Hua, Su, Mei-Chi, Tien, Ni, Huang, Chien-Jhen, Lan, Yu-Ching, Lin, Chen-Sheng, Chen, Chao-Hsien, Lin, Cheng-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105056/
https://www.ncbi.nlm.nih.gov/pubmed/26746130
http://dx.doi.org/10.1016/j.jmii.2015.10.008
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author Huang, Su-Hua
Su, Mei-Chi
Tien, Ni
Huang, Chien-Jhen
Lan, Yu-Ching
Lin, Chen-Sheng
Chen, Chao-Hsien
Lin, Cheng-Wen
author_facet Huang, Su-Hua
Su, Mei-Chi
Tien, Ni
Huang, Chien-Jhen
Lan, Yu-Ching
Lin, Chen-Sheng
Chen, Chao-Hsien
Lin, Cheng-Wen
author_sort Huang, Su-Hua
collection PubMed
description BACKGROUND/PURPOSE: Human coronavirus (HCoV) NL63 is recognized in association with upper or lower respiratory tract illnesses in children. This study surveyed the prevalence of HCoV-NL63 and influenza viruses in patients with influenza-like illness in Taiwan during 2010–2011. METHODS: Throat samples from 107 hospitalized patients with pneumonia and 175 outpatients with influenza-like illness were examined using real-time polymerase chain reaction assays with virus-specific primers, and then virus-positive specimens were confirmed by sequencing the polymerase chain reaction products. RESULTS: HCoV-NL63 infection was identified in 8.4% (9/107) of hospitalized patients with pneumonia, but not found in outpatients with influenza-like illness. Age distribution of HCoV-NL63 infection in hospitalized patients with pneumonia indicated that the group aged 16–25 years (20%) had the highest positive rate compared with the other groups, and exhibited a similar age-specific pattern to influenza A/H1N1 infection, but not influenza A/H3N2 and B infections in hospitalized patients. Seasonal prevalence of HCoV-NL63 infection was late winter, overlapping the highest peak of the influenza A/H1N1 epidemic during December 2010 to March 2011 in Taiwan. Co-infection of HCoV-NL63 and influenza A/H1N1 was detected in three hospitalized patients. Clinical manifestation analysis indicated that the main symptoms for HCoV-NL63 infection included fever (88.9%), cough (77.8%), and pneumonia (100%). Co-infection caused significantly higher rates of breathing difficulties, cough, and sore throat than those of single infection with HCoV-NL63 and influenza A/H1N1. Phylogenetic analysis indicated a low level of heterogeneity between Taiwan and global HCoV-NL63 strains. CONCLUSION: Understanding epidemiology of HCoV-NL63 in Taiwan provides an insight for worldwide surveillance of HCoV-NL63 infection.
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spelling pubmed-71050562020-03-31 Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan Huang, Su-Hua Su, Mei-Chi Tien, Ni Huang, Chien-Jhen Lan, Yu-Ching Lin, Chen-Sheng Chen, Chao-Hsien Lin, Cheng-Wen J Microbiol Immunol Infect Article BACKGROUND/PURPOSE: Human coronavirus (HCoV) NL63 is recognized in association with upper or lower respiratory tract illnesses in children. This study surveyed the prevalence of HCoV-NL63 and influenza viruses in patients with influenza-like illness in Taiwan during 2010–2011. METHODS: Throat samples from 107 hospitalized patients with pneumonia and 175 outpatients with influenza-like illness were examined using real-time polymerase chain reaction assays with virus-specific primers, and then virus-positive specimens were confirmed by sequencing the polymerase chain reaction products. RESULTS: HCoV-NL63 infection was identified in 8.4% (9/107) of hospitalized patients with pneumonia, but not found in outpatients with influenza-like illness. Age distribution of HCoV-NL63 infection in hospitalized patients with pneumonia indicated that the group aged 16–25 years (20%) had the highest positive rate compared with the other groups, and exhibited a similar age-specific pattern to influenza A/H1N1 infection, but not influenza A/H3N2 and B infections in hospitalized patients. Seasonal prevalence of HCoV-NL63 infection was late winter, overlapping the highest peak of the influenza A/H1N1 epidemic during December 2010 to March 2011 in Taiwan. Co-infection of HCoV-NL63 and influenza A/H1N1 was detected in three hospitalized patients. Clinical manifestation analysis indicated that the main symptoms for HCoV-NL63 infection included fever (88.9%), cough (77.8%), and pneumonia (100%). Co-infection caused significantly higher rates of breathing difficulties, cough, and sore throat than those of single infection with HCoV-NL63 and influenza A/H1N1. Phylogenetic analysis indicated a low level of heterogeneity between Taiwan and global HCoV-NL63 strains. CONCLUSION: Understanding epidemiology of HCoV-NL63 in Taiwan provides an insight for worldwide surveillance of HCoV-NL63 infection. Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. 2017-12 2015-11-19 /pmc/articles/PMC7105056/ /pubmed/26746130 http://dx.doi.org/10.1016/j.jmii.2015.10.008 Text en © 2015 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Huang, Su-Hua
Su, Mei-Chi
Tien, Ni
Huang, Chien-Jhen
Lan, Yu-Ching
Lin, Chen-Sheng
Chen, Chao-Hsien
Lin, Cheng-Wen
Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan
title Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan
title_full Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan
title_fullStr Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan
title_full_unstemmed Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan
title_short Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan
title_sort epidemiology of human coronavirus nl63 infection among hospitalized patients with pneumonia in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105056/
https://www.ncbi.nlm.nih.gov/pubmed/26746130
http://dx.doi.org/10.1016/j.jmii.2015.10.008
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